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MetabolomicsGeneration of a chromosome-scale genome assembly of the insect-repellent terpenoid-producing Lamiaceae species, Callicarpa americana

BACKGROUND: Plants exhibit wide chemical diversity due to the production of specialized metabolites that function as pollinator attractants, defensive compounds, and signaling molecules. Lamiaceae (mints) are known for their chemodiversity and have been cultivated for use as culi...

2020-12-04 | MTBLS1983 | MetaboLights
ProteomicsArctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
Arctigenin (ATG) is a major component of Fructus Arctii, which as a traditional herbal remedy reduced proteinuria in diabetic patients. However, whether ATG specifically provided renoprotection in DKD was not known. Here we report that ATG administration is sufficient to attenuate proteinuria and po...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD014976 | Pride
Actin cytoskeleton Podocytes Pp2a Drebrin-1 Arctigenin Diabetic kidney disease 
UnknownProgressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome in seven patients with sarcoidosis: a critical discussion of treatment and prognosis.
Not available
S-EPMC8326823 | biostudies-literature
TranscriptomicsComparison of Glomerular and Podocyte mRNA Profiles in eNOS-/- Diabetic Mice Induced by Streptozotocin
We compared mRNA profiles of isolated glomeruli versus sorted podocytes between diabetic and control mice. IRG mice crossed with eNOS-/- mice were further bred with podocin-rTTA and TetON-Cre mice to permanently label podocytes before the diabetic injury. Diabetes was induced by injection of strepto...
ORGANISM(S): Mus musculus 
2016-03-16 | E-GEOD-79291 | biostudies-arrayexpress
TranscriptomicsPriming defense genes and metabolites in hybrid poplar by the green leaf volatile cis-3-hexenyl acetate
• Herbivore-induced plant volatiles (HIPVs), in addition to attracting natural enemies of herbivores, can serve a signaling function within plants by acting as wound signals that induce or prime defenses. However, particularly in woody plants, which compounds within HIPV blends are capable of act...
ORGANISM(S): Populus x canadensis 
2010-05-25 | E-GEOD-11955 | biostudies-arrayexpress
UnknownTransplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency.
Not available
S-EPMC6101191 | biostudies-literature
UnknownClinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project.
Not available
S-EPMC6520241 | biostudies-literature
ProteomicsHuman Immunoglobulin Repertoire-Guided Immunogen Design Targeting HIV V2-Apex Broadly Neutralizing Antibody Precursors
Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an uncommonly long heavy chain complementarity-determining region 3 (HCDR3), suggesting that rarity of bnAb precursors poses a challenge for...
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 
2023-03-11 | PXD033766 | Pride
Hiv antibodies Aids vaccines Structural vaccinology Immunoinformatics 
UnknownGlobal trends in molecular epidemiology of HIV-1 during 2000-2007.
Not available
S-EPMC3755761 | biostudies-literature
UnknownA genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
Not available
S-EPMC3335297 | biostudies-literature
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