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TranscriptomicsSingle-cell RNA sequencing of erythroid and megakaryocytic acute myeloid leukemia patient cells
Single-cell RNA sequencing was performed on bone marrow mononuclear of a patient with acute myeloid leukemia with erythroid differentiation of the blasts and on peripheral blood mononuclear cells of a patient with acute myeloid leukemia with megakaryocytic differentiation of the blasts. Raw data for...
ORGANISM(S): Homo sapiens 
2022-12-05 | E-MTAB-12607 | biostudies-arrayexpress
ProteomicsDT2216 is a specific BCL-XL PROTAC
To validate the specificity of DT2216, we used the stable isotope labeling with amino acids in cell culture (SILAC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics to analyze the changes in proteins in WI-38 normal human diploid fibroblasts after DT2216 and DT2216NC tr...
ORGANISM(S): Homo sapiens (Human) 
2019-10-08 | PXD010878 | Pride
Dt2216 bcl-xl protac silac lc-ms/ms 
TranscriptomicsGene expression comparison of wild-type and IL15ko thymic NKT cells
Semi-invariant natural killer T (NKT) cells are thymus-derived innate lymphocytes that modulate microbial and tumour immunity as well as autoimmune diseases. These immunoregulatory properties of NKT cells are acquired during their development. Much has been learnt regarding the molecular and cell...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-32568 | biostudies-arrayexpress
UnknownTargeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma.
Not available
S-EPMC12930748 | biostudies-literature
UnknownMapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL.
Not available
S-EPMC10762229 | biostudies-literature
UnknownDimethyl fumarate abrogates hepatocellular carcinoma growth by inhibiting Nrf2/Bcl-xL axis and enhances sorafenib's efficacy.
Not available
S-EPMC12078513 | biostudies-literature
UnknownUtilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL.
Not available
S-EPMC7057339 | biostudies-literature
UnknownCHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation.
Not available
S-EPMC4423185 | biostudies-literature
UnknownA selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.
Not available
S-EPMC6898785 | biostudies-literature
UnknownDiscovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines.
Not available
S-EPMC7325632 | biostudies-literature
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