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MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsQuantitative analysis of the antibacterial effect of cinnamaldehyde on Staphylococcus aureus based on TMT protein
TMT quantitative proteomics was used to analyze the changes of protein expression in MRSA under the action of CA, and the antibacterial mechanism of CA on MRSA was further revealed.
ORGANISM(S): Staphylococcus Aureus 
2024-08-14 | PXD054851 |
ProteomicsQuantitative proteomics reveals the protective mechanism of glutamine against enteritis in hybrid groupers
Five experimental diets were prepared with equal levels of protein (48% crude protein) and lipid (12% crude lipid): a diet based on fishmeal (referred to as Group FM), a diet containing 7% β-conglycinin (referred to as Group 7S), a diet containing 10% glycinin (referred to as Group 11S), a β-congl...
ORGANISM(S): Epinephelus Fuscoguttatus X Epinephelus Lanceolatus 
2023-08-23 | PXD044757 |
Proteomics,MultiomicsHs_HCC_r2
CHPP chr 1,8,20 proteome dataset using the HCC cell lines of MHCC97H and HCCLM3, part 2
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe005197 | PeptideAtlas
Proteomics,MultiomicsHs_HCC_r3
CHPP chr 1,8,20 proteome dataset using the HCC cell lines of MHCC97H and HCCLM3, part 3
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe005194 | PeptideAtlas
Proteomics,MultiomicsHs_HCC_r1
CHPP chr 1,8,20 proteome dataset using the HCC cell lines of MHCC97H and HCCLM3, part 1
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe005189 | PeptideAtlas
ProteomicsPotential binding proteins of CAV3 obtained from LC-MS/MS
To gain further insight into the molecular mechanisms of CAV3 in DCM. we conducted liouid chromatography-tandem mass spectrometry (LC-MS/MSassays to identify potential binding proteins of CAV3 in cardiomyocytes.LC-MS/MS was conducted by SpecAly Life Technology Co, Ltd. (Wuhan, China).
ORGANISM(S): Homo Sapiens 
2023-08-21 | PXD044674 |
ProteomicsCBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2
Molecular mechanisms of HIV-1 latency have been studied extensively to achieve a functional cure for the acquired immunodeficiency syndrome (AIDS). To develop more promising latency-reversing agents (LRAs) to efficiently reactivate the latent reservoir which is subsequently eliminated by immune surv...
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD031011 |
ProteomicsAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
To determine the molecular landscape of large intestinal aging, we collected 104 pieces of fresh large intestinal tissue from 26 Macaca fascicularis and performed age-, location-, and sex-resolved multi-omics analyses, including transcriptomics, proteomics, phosphoproteomics and metabolomics.
ORGANISM(S): Macaca Fascicularis Fascicularis 
2024-01-18 | PXD039361 |
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