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Proteomicssystematic proteomic of 20 cases of primary ESCC tumor tissue (T), matched normal tissue (N) and lymph node metastatic tissue (LN)
To obtain the global landscape of Khib in ESCC metastasis, 20 cases of primary ESCC tumor tissue (T), matched normal tissue (N) and lymph node metastatic tissue (LN) were subjected to systematic proteomic.
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD037295 | Pride
Proteomics Cancer metastasis 
ProteomicsAnalysis of muscular proteomics of deep pressure ulcers reveals JAK2 influence on muscle autophagy and apoptosis
Pressure ulcers (PU) is a complex and serious clinical problem. Deep tissue injury is either the outcome or the trigger of deep PU. However, the cellular and molecular mechanisms that contribute to the pathogenesis of deep PU remain unclear. In this study, the degeneration characteristics, increased...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009512 | Pride
Proteomics Ischemia/reperfusion injury Deep pressure ulcers Jak2 Autophagy & apoptosis 
ProteomicsTFAM Binds to and Promotes Mutagenic Transcriptional Bypass of O4-Alkylthymidine Lesions
O2- and O4-alkylated thymidine lesions are known to be poorly repaired and persist in mammalian tissues. To understand how mammalian cells sense the presence and regulate the repair of these lesions, we employed a stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative prot...
ORGANISM(S): Homo sapiens (Human) 
2020-12-21 | PXD021719 | Pride
Dna damage Tfam Proteomics Lc-ms/ms 
ProteomicsA Comprehensive Interrogation of Mirror-Image L-RNA-Protein Interactome Reveals Key Mechanisms of L-RNA Cytotoxicity
L-Oligonucleotides (ONs), the synthetic enantiomer of native D-nucleic acids, are being increasingly utilized for the development of diverse biomedical technologies, including molecular imaging tools, diagnostic biosensors, and aptamer-based therapeutics. Nevertheless, our understanding of how L-ONs...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD054780 | Pride
L-oligonucleotides • spiegelmers • cytotoxicity • silac • protein binding 
ProteomicsSerum proteome analysis identifies a potential biomarker for axial psoriatic arthritis
Serum samples were collected from patients with PsA to create a biomarker discovery cohort and a validation cohort. Patients with PsA were classified into axial or peripheral subtypes based on imaging criteria. Liquid chromatography-mass spectrometry was used in the discovery phase to screen for bio...
ORGANISM(S): Homo Sapiens 
PXD044598 |
TranscriptomicsA Genome-wide mRNA Screen and Functional Analysis Reveal FOXO3 as a Candidate Gene for Chicken Growth
The objective of this study was to identify candidate genes associated with chicken growth and investigate their potential mechanisms. We used RNA-Seq to study the breast muscle transcriptome in high and low tails of Recessive White Rock (WRRh, WRRl) and Xinghua chickens (XHh, XHl). A total of 60, 2...
ORGANISM(S): Gallus gallus 
2015-08-27 | E-GEOD-72424 | biostudies-arrayexpress
ProteomicsProteomics reveals the inhibitory mechanism of Levodopa against esophageal squamous cell carcinoma
The high recurrence rate and poor survival prospects of esophageal squamous cell carcinoma (ESCC) patients after treatment make the ongoing research on chemoprevention drugs for ESCC particularly important. In helping to solve this problem, we screened a large number of FDA-approved drugs and found ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013824 | Pride
Mitochondria Levodopa Chemoprevention Esophageal squamous cell carcinoma (escc) 
ProteomicsDysregulation of phophoproteins in hepatocellular carcinoma revealed by the quantitative analysis of phosphoproteome
Hepatocellular carcinoma is one of the most frequently diagnosed cancers in the world. Post-translational modifications (PTMs) play an essential role during cancer development. Phosphorylation is an important PTMs. To identify the modifications of phosphorylation in HCC, a multiplexed tandem mass ta...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD013934 | Pride
Hepatocellular carcinoma Lc−ms/ms Phophoproteins 
ProteomicsMorphological and proteomic analyses in petioles rigidity: evidence towards phenotypic plasticity in sacred lotus for aquatic environment
Very little is known about the mechanism controlling petiole rigidity in sacred lotus (Nelumbo nucifera Gaertn.). To investigate the mechanism controlling the lotus petiole rigidity, morphological and proteomic analyses were performed. Anatomically, there is a great variation between the petioles of...
ORGANISM(S): Nelumbo nucifera (Sacred lotus) 
2021-07-29 | PXD009136 | Pride
Proteomics Sacred lotus Petiole rigidity Cell wall Lignin biosynthesis 
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