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ProteomicsDysregulation of phophoproteins in hepatocellular carcinoma revealed by the quantitative analysis of phosphoproteome
Hepatocellular carcinoma is one of the most frequently diagnosed cancers in the world. Post-translational modifications (PTMs) play an essential role during cancer development. Phosphorylation is an important PTMs. To identify the modifications of phosphorylation in HCC, a multiplexed tandem mass ta...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD013934 | Pride
Hepatocellular carcinoma Lc−ms/ms Phophoproteins 
ProteomicsPhosphoproteomic Landscape of Pseudorabies Virus Infection Reveals Multiple Potential Antiviral Targets
A quantitative phosphoproteome was conducted to explore the phosphorylation changes and host cellular responses upon PRV infection. Besides, the characteristics of the phosphorylated proteins were analyzed, including molecular distribution, percentage of the phosphorylated (STY) sites, and phosphory...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-11-17 | PXD044682 | Pride
Phosphoproteomic landscape Pseudorabies virus Antiviral targets Virus-host interaction 
ProteomicsProtein and Signaling Pathway Responses to rhIL-6 Intervention before Lobaplatin Treatment in Osteosarcoma Cells using Quantitative Phosphoproteome Analysis
IL-6 plays a pivotal role in the process of drug resistance to kinds of chemotherapeutics including lobaplatin. However, the underlying changes of phosphoproteins and related signaling pathways in the posttranslational modification level is still uncover. In our study, a quantitative phosphoproteome...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025970 | Pride
Human Phosphoproteome analysis Lobaplatin Il-6 Osteosarcoma 
ProteomicsChromosomal instability adaptation dependencies confer unique targetable vulnerabilities in therapy refractory lethal prostate cancer
Chromosomal instability (CIN), an ongoing rate of chromosome missegregation during mitosis, is a defining feature of cancer. However, high chromosomal aberrations are detrimental for cell fitness. Here we investigated mechanisms allowing lethal prostate cancer (PCa) to tolerate and survive increasin...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD028271 | Pride
Mastl expression Chromosomal instability 
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