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TranscriptomicsAnalysis of mouse T cell transcription profile after co-culture with BaF3 cells with or without the oncogenic point mutation JAK2 V617F
The activation of PD-1 (Programmed Death receptor-1) on T cells can cause T cell exhaustion and immune tolerance. Some tumors up-regulate the expression of the ligand of PD-1, namely PD-L1 (Programmed Death Receptor-Ligand 1), thus preventing anti-tumor immune response and promoting immune-escape. P...
ORGANISM(S): Mus musculus 
2018-12-01 | E-MTAB-5028 | biostudies-arrayexpress
ProteomicsAnalysis of muscular proteomics of deep pressure ulcers reveals JAK2 influence on muscle autophagy and apoptosis
Pressure ulcers (PU) is a complex and serious clinical problem. Deep tissue injury is either the outcome or the trigger of deep PU. However, the cellular and molecular mechanisms that contribute to the pathogenesis of deep PU remain unclear. In this study, the degeneration characteristics, increased...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009512 | Pride
Proteomics Ischemia/reperfusion injury Deep pressure ulcers Jak2 Autophagy & apoptosis 
TranscriptomicsMurine Ba/F3 Cells: Ba/F3 cells expressing wild type JAK2 (WT cells) vs. Ba/F3 cells expressing JAK2 V617F mutant (VF cells)
Transcriptional profiling of transformed Ba/F3 cells by myeloproliferative neoplasm-associated JAK2 V617F mutant comparing control Ba/F3 cells expressing wild type JAK2. Two-condition experiment, WT cells vs. VF cells. One replicate per array.
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-34239 | biostudies-arrayexpress
TranscriptomicsGenetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predispose to myeloproliferative neoplasms
Genome-wide association study of JAK2 V617F negative myeloproliferative neoplasms consisting of 524 cases at stage 1
ORGANISM(S): Homo sapiens 
2015-02-20 | E-MTAB-3340 | biostudies-arrayexpress
ProteomicsSplicing factor Ybx1 maintains persistent Jak2-mutated neoplasms via Mknk1-ERK-signaling
Janus kinases (Jak) mediate cytokine, hormone and growth factor responses in hematopoietic cells. Jak2 is one of the most frequently mutated genes in the aging hematopoietic system and in hematopoietic cancers. Mutations in Jak constitutively activate downstream signaling and are drivers of myelopro...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-20 | PXD006921 | Pride
Mpn Phosphoproteome Jak2 Hematological malignancy Splicing factor Erksignaling Ybx1 
TranscriptomicsCooperative Epigenetic Modulation by Cancer Amplicon Genes
Amplification of a ~2.5 megabase region on chromosome 9p24 is frequent in both primary mediastinal B-cell lymphoma (PMBL) and Hodgkin's lymphoma (HL). To identify the oncogenic genes in this interval, we created a RNA interference library targeting amplicon genes. A genetic screen using this library...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-20988 | biostudies-arrayexpress
ModelsAdlung2021 - Cell-to-cell variability in JAK2/STAT5 pathway
A mathematical model for cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells
2024-09-02 | BIOMD0000001077 | BioModels
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54645 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in JAK2 exon 12-mutant erythroblasts
For 13 patients with JAK2 exon 12-mutated polycythemia vera (PV), we compared genome-wide RNA profiles of JAK2-mutant (mutant) and wild-type erythroid colonies, grown from a single patient in the same culture plate. This paired approach controls for factors including age, gender, treatment, germline...
ORGANISM(S): Homo sapiens 
2015-10-04 | E-MTAB-3946 | biostudies-arrayexpress
GenomicsSPAG9-JAK2 gene expression array in Ba/F3 cells
SPAG9-JAK2 gene expression array in Ba/F3 cells
PRJNA730570 | ENA
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