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MetabolomicsM3-Driven Hexosamine Biosynthesis Facilitates Hepatocellular Carcinoma Progression through YBX1 O-GlcNAcylation
Phosphoglucomutase 3 (PGM3) is one of the rate-limiting enzymes in the hexosamine biosynthesis pathway (HBP) and a key regulator of HBP metabolic flux. Despite the functional role of PGM3 has been validated in various tumors, its function and molecular mechanism in hepatocellular carcinoma (HCC) rem...
2026-09-04 | MTBLS15552 | MetaboLights
MetabolomicsPGM3-Driven Hexosamine Biosynthesis Facilitates Hepatocellular Carcinoma Progression through YBX1 O-GlcNAcylation (Untargeted metabolomics)
Phosphoglucomutase 3 (PGM3) is one of the rate-limiting enzymes in the hexosamine biosynthesis pathway (HBP) and a key regulator of HBP metabolic flux. Despite the functional role of PGM3 has been validated in various tumors, its function and molecular mechanism in hepatocellular carcinoma (HCC) rem...
2026-09-03 | MTBLS15545 | MetaboLights
ProteomicsYBX1 interacting protein - C1QBP Negatively Regulates the Activation of Oncoprotein YBX1 in the Renal Cell Carcinoma As Revealed by Interactomics Analysis
The Y-box-binding protein 1 (YBX1) plays a critical role in tumorigenesis by promoting cell proliferation, overriding cell-cycle check points, and enhancing genomic instability. In this study, the interactome of YBX1 in renal cell carcinoma (RCC) was analyzed by coimmunoprecipitation and mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2015-01-30 | PXD001493 | Pride
Human Renal cancer Ybx1 Lc-ms/ms 
ProteomicsYBX1 mediates translation of oncogenic transcripts to control cell competition in AML
Persistence of malignant clones following cytotoxic or targeted therapy is a major determinant of adverse outcome in patients with hematologic malignancies. Despite the fact that the majority of patients with acute myeloid leukemia (AML) achieve complete remission after chemotherapy, a large proport...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026329 | Pride
Oncogene Proteome Translation Ybx1 Aml 
ProteomicsYBX1-IP in mouse bone marrw myeloma cells
The total protein of bone marrw myeloma cells was extracted with cell lysis buffer for IP. YBX1 antibody was used to perform Immunoprecipitation.
ORGANISM(S): Mus musculus (Mouse) 
2023-04-19 | PXD039386 | Pride
Bmscs Ybx1-ip 
TranscriptomicsYBX1-dependent hypoxia-induced modulation of gene expression
In order to identify YBX1-dependent targets that are modulated under hypoxic conditions, we used control and YBX1 knockdown cells grown under normoxia and hypoxia to profile gene expression levels. Control and YBX1-knockdown cells were grown and profiled under hypoxia and normoxia to identify YBX1-d...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-63562 | biostudies-arrayexpress
TranscriptomicsYBX1-dependent LNA-tRF-mediated modulation of gene expression
In order to identify YBX1-dependent targets that are modulated upon changing the levels of endogenous tRFs, we used transient transfection of antisense locked-nucleic acids (LNAs) against tRFAsp, tRFGly, tRFGlu, and tRFTyr followed by microarray profiling. Synthetic antisense locked-nucleic acids (L...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-63564 | biostudies-arrayexpress
TranscriptomicsYBX1-dependent LNA-tRF-mediated modulation of transcript stability
In order to identify YBX1-dependent targets that are modulated upon changing the levels of endogenous tRFs, we used transient transfection of antisense locked-nucleic acids (LNAs) against tRFAsp, tRFGly, tRFGlu, and tRFTyr followed by alpha-amanitine treatment, RNA extraction at time points 0 and 8h...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-63565 | biostudies-arrayexpress
TranscriptomicsYBX1-dependent LNA-tRF-mediated modulation of gene expression under hypoxia
In order to test whether inhibition of tRFs induced under hypoxia would counteract the YBX1-dependent reduction of target transcripts, we used transient transfection of antisense locked-nucleic acids (pooled LNAs) against tRFAsp, tRFGly, tRFGlu, and tRFTyr under hypoxia followed by microarray profil...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-63563 | biostudies-arrayexpress
ProteomicsGasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway
Pancreatic ductal adenocarcinoma (PDAC) originates from normal pancreatic ducts where digestive juice is regularly produced. It remains unclear how PDAC can escape auto-digestion by digestive enzymes. Here we show that human PDAC tumor cells use gasdermin E (GSDME), a pore-forming protein upon caspa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030879 | Pride
Gsdme，pancreatic ductal adenocarcinoma，ybx1 Mucin 
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