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MetabolomicsMitochondrial Transplantation Ameliorates Doxorubicin-Induced Cardiac Dysfunction via Activating Glutamine Metabolism
Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to be one of the pathogeneses of doxorubicin-induced myocardial injury. In this study, we test the hypothesis that mitoch...
2025-03-13 | MTBLS7989 | MetaboLights
MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
ProteomicsAlternative preservation strategies of hearts donated after circulatory death: The effect of extended CIT before NMP
Donation after circulatory death (DCD) offers a promising strategy to expand the donor pool by 20–30%. However, DCD heart grafts suffer from warm ischemia injury, making effective graft viability assessment before transplantation prudent. Current methods for assessing DCD hearts are impacted either ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-08-24 | PXD067097 | Pride
Hearts transplantation  swine  cold ischemia  warm ischemia  tissue donors  hypothermia  proteomics  perfusion 
TranscriptomicsmicroRNA expression in heart tissue
Ischemia reperfusion (I/R) injury is an unavoidable event occurring during heart transplantation, leading to graft failures and lower long-term survival rate of the recipient. microRNAs are major regulators of genes. IR causes apoptosis/death of cardiomyocytes, resulting from up-regulation of apopt...
ORGANISM(S): Mus musculus 
2013-09-17 | E-GEOD-50885 | biostudies-arrayexpress
TranscriptomicsGene expression following myocardial infarction with and without stem cell transplantation
Background: Bone marrow-derived multipotent progenitor cell (MPC) transplantation leads to short term functional and bioenergetic improvement in a porcine model of postinfarction Left Ventricular (LV) remodeling despite a low engraftment rate. However, the long term outcome after MPC transplantation...
ORGANISM(S): Sus scrofa 
2010-04-12 | E-GEOD-14643 | biostudies-arrayexpress
ProteomicsIdentifying Compartment-specific Alloimmune Targets After Renal Transplantation by integrated genomics
Microarray technology has evolved as a powerful tool over the last decade, to identify biomarkers and study the mechanisms of diseases. We propose a novel application of integrated genomics by combining transcriptional levels with serological antibody profiling after kidney transplantation, with the...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10452 | biostudies-arrayexpress
TranscriptomicsExpression data from heart tissue
Ischemia reperfusion (I/R) injury is an unavoidable event occurring during heart transplantation, leading to graft failures and lower long-term survival rate of the recipient. IR causes apoptosis / death of cardiomyocytes, resulting from up-regulation of apoptotic genes and down-regulation of anti-a...
ORGANISM(S): Mus musculus 
2013-09-17 | E-GEOD-50884 | biostudies-arrayexpress
UnknownCost-effectiveness of using hepatitis C viremic hearts for transplantation into HCV-negative recipients.
Not available
S-EPMC8216294 | biostudies-literature
TranscriptomicsGene expression analysis in non-failing and failing myocardium pre and post pulsatile and non-pulsatile VAD support
Mechanical unloading by ventricular assist devices (VAD) leads to significant gene-expression changes often summarized as reverse remodeling. However, little is known on individual transcriptome changes during VAD-support and its relationship to non-failing hearts (NF). In addition no data are avail...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-21610 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of rat hearts after kidney transplantation in chronic kidney disease model
Transcriptomes from hearts of control and CKD rats after transplantation of healthy kidney and kidney from CKD animal.
ORGANISM(S): Rattus norvegicus 
2019-10-01 | GSE88910 | GEO
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