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ProteomicsPhosphoproteomic analyses reveal novel cross-modulation mechanisms between two signaling pathways in yeast
Cells respond to environmental stimuli via specialized signaling pathways. Concurrent stimuli trigger multiple pathways that integrate information, predominantly via protein phosphorylation. Budding yeast respond to NaCl and pheromone via two mitogen-activated protein kinase cascades, the high osmo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-12-19 | PXD001445 | Pride
Budding yeast Signaling pathways Phospho-proteomics 
UnknownMechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5.
Not available
S-EPMC6719448 | biostudies-literature
ProteomicsMutagenesis of Key Phosphodiesterases in Toxoplasma gondii Demonstrates the Plasticity and Therapeutic Potential of Cyclic Nucleotide Signaling
Cyclic nucleotide signaling is pivotal to the asexual growth of T. gondii; however, little do we know about its counter-regulation in this parasite. We identified 18 phosphodiesterase (PDE1-18) enzymes, most of which form apicomplexan-specific clades and lack typical regulatory motifs found in mamma...
ORGANISM(S): Cellular Organisms 
2023-02-22 | PXD032173 | JPOST Repository
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