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ProteomicsCDK and MAPK collaborate to regulate signaling dynamics via multi-site phosphorylation of the scaffold protein Ste5
CDKs and MAPKs phosphorylate similar sites yet generally have distinct functions/substrates. We report here an unanticipated system of cooperative regulation by CDK and MAPK, involving collaborative multi-site phosphorylation of a single substrate. The budding yeast protein Ste5 is a signaling scaff...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-03-12 | PXD006154 | Pride
Yeast Cdk Phospho proteomics Mapk Ste5 Pheromone response 
ProteomicsExternal and intrinsic mechanical stress restricts pheromone signaling by direct phosphorylation of the Ste5 scaffold by Pkc1
Ste5 and Far1 function as prototypical scaffold proteins activating a MAP-kinase cascade and polarizing yeast cells in response to pheromones. Here we show that Pkc1-dependent phosphorylation of conserved serine residues in their RING-H2 domains down-regulates pheromone induced signaling upon mechan...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-06-17 | PXD004657 | Pride
Yeast Saccharomyces cerevisiae Scaffold Mapk Ste5 Far1 
UnknownDimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction.
Not available
S-EPMC19450 | biostudies-literature
UnknownMitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae.
Not available
S-EPMC549360 | biostudies-literature
UnknownMechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5.
Not available
S-EPMC6719448 | biostudies-literature
UnknownThe Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation.
Not available
S-EPMC2777755 | biostudies-literature
UnknownNegative Feedback Phosphorylation of Gγ Subunit Ste18 and the Ste5 Scaffold Synergistically Regulates MAPK Activation in Yeast.
Not available
S-EPMC5987779 | biostudies-literature
UnknownCDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5.
Not available
S-EPMC5858200 | biostudies-literature
UnknownEffects of HSP70 chaperones Ssa1 and Ssa2 on Ste5 scaffold and the mating mitogen-activated protein kinase (MAPK) pathway in Saccharomyces cerevisiae.
Not available
S-EPMC10584130 | biostudies-literature
UnknownDifferential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes.
Not available
S-EPMC449765 | biostudies-literature
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