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TranscriptomicsTranscription profiling of human small airway bronchial epithelium to assess gene expression in phenotypically normal smokers compared to matched non-smokers
The earliest morphologic evidence of changes in the airways associated with chronic cigarette smoking is in the small airways. To help understand how smoking modifies small airway structure and function, we developed a strategy using fiberoptic bronchoscopy and brushing to sample the human small air...
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3320 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human alveolar macrophages from phenotypically normal smokers compared to non-smokers to identify new genes linking to early events in the molecular pathogenesis of COPD
Cigarette smoking is the leading cause of the respiratory diseases collectively known as chronic obstructive pulmonary disease (COPD). While the pathogenesis of COPD is complex, there is abundant evidence that alveolar macrophages (AM) play an important role. Based on the concept that COPD is a slow...
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3212 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human airway epithelium, large airways, phenotypically normal smokers vs non-smokers, MAS5 (HuGeneFL)
Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers; The microarray data deposited here is from 44 HuGeneFL GeneChips, from 9 normal non-smokers and 13 phenotypic normal smokers, large airways, 2 samples per individual, one ...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-5056 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human airway epithelium, large airways, from phenotypically normal smokers vs non-smokers
Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers; The microarray data deposited here is from 11 HG-U133A GeneChips, from 5 normal non-smokers and 6 phenotypic normal smokers, large airways. Samples from the small airways ...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-5057 | biostudies-arrayexpress
TranscriptomicsCalorie restriction suppresses age-dependent hippocampal transcriptional signatures.
Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous species. Physiological responses to CR are cell-type specific and variable throughout the lifespan; however, the mosaic of molecular changes responsible CR benefits remain unclear, particularly in brain regions su...
ORGANISM(S): Mus musculus 
2015-07-14 | E-GEOD-69952 | biostudies-arrayexpress
UnknownPrevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer.
Not available
S-EPMC3753703 | biostudies-literature
TranscriptomicsNovel kinase fusion oncogenes in post-Chernobyl radiation-induced pediatric thyroid cancers
Exposure to ionizing radiation during childhood markedly increases the risk of developing papillary thyroid cancer. We identified non-overlapping somatic driver mutations in all 26 cases of post-Chernobyl thyroid cancers we studied through candidate gene assays and next generation RNA-sequencing. We...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-48850 | biostudies-arrayexpress
GenomicsInvestigation of breast cancer-associated mutations in RND1 gene
We identified the Rho family GTPase Rnd1 as a candidate breast tumor suppressor by using bioinformatics analysis in conjunction with iRNA silencing. Upon silencing of Rnd1, normal mammary epithelial cells underwent a complete EMT but eventually became senescent, suggesting that they had experienced ...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-43828 | biostudies-arrayexpress
Transcriptomics18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for th...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
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