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ProteomicsABPP-HT - high-throughput activity-based profiling of deubiquitylating enzyme inhibitors in a cellular context
The potency and selectivity of a small molecule inhibitor are key parameters to assess during the early stages of drug discovery. In particular, it is very informative for characterizing compounds in a relevant cellular context in order to reveal potential off-target effects and drug efficacy. Activ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-24 | PXD023036 | Pride
Drug discovery Pharmacology Activitomics Deubiquitylating enzymes Ubiquitin Automation Activity-based probes 
ProteomicsGlobal proteomic analysis of extracellular matrix in mouse and human brain highlights association with cerebrovascular disease
The extracellular matrix (ECM), a key interface between the cerebrovasculature and other cells within the neuro-glial-vascular unit , provides structural stability and modulates cell behaviour and signalling. These functions are dependent on ECM protein composition. Since ECM defects may contribute ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-03-11 | PXD020436 | Pride
Ecm Basement membrane Cerebrovascular Matrisome Proteome Extracellular matrix 
ProteomicsFunctional analysis of a gene-edited mouse to gain insights into the disease mechanisms of a TITIN missense variant
Aims: Pathogenic truncating variants in the largest human protein TITIN are a leading cause of dilated cardiomyopathy. Because of the size of the gene encoding TITIN, many missense variations are identified. These are difficult to evaluate in genetic testing, as even individually rare variants are c...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-01 | PXD020390 | Pride
Proteomics Proteo-toxic response Telethonin Mouse model Proteasome Titin missense variant Cardiomyopathy 
ProteomicsActivity-based profiling of deubiquitylating enzymes
This set is a repackaging of PXD031848 (described in https://doi.org/10.3390/ijms23063263: "ABPP-HT*-Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods") to make each LC-MS/MS experiment individually downloadable and to include TIMSC...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-24 | MSV000095426 | MassIVE
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