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GenomicsMeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the central nervous system (CNS) may differ from those present in embryonic stem cells. Here we present quantitative, genome-wide analysis of 5hmC, 5- methylcytosine (5mC) an...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-42880 | biostudies-arrayexpress
TranscriptomicsApplication of a translational profiling approach for the comparative analysis of CNS cell types.
Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, Translating Ribosome Affinity Purification (TRAP), permits comprehensive studies of translated mRNAs in genetically defined cell populations following physiological perturb...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13379 | biostudies-arrayexpress
TranscriptomicsTranslational profiling of hypocretin neurons identifies Lhx9 as necessary for normal development of the hypocretinergic system.
The immense molecular diversity of neurons challenges our ability to deconvolve the relationship between the genetic and the cellular underpinnings of neuropsychiatric disorders. Hypocretin (orexin) containing neurons of the lateral hypothalamus are clearly essential for the normal regulation of sle...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-38668 | biostudies-arrayexpress
TranscriptomicsComparative analysis of different cortical interneuron groups.
GABAergic interneuron in the cortex comprise a very heterogenous group. and it is critical to identify discrete interneuron types to understand how their contributions to behavior can be modulated by external and internal cues. However, molecular difinition of these interneuron cell groups has been ...
ORGANISM(S): Mus musculus 
2014-10-07 | E-GEOD-56996 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons and Drd2+ Medium Spiny Neurons
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13384 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons, cocaine treatment
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13386 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons, Motor Neurons, and Purkinje Neurons
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13387 | biostudies-arrayexpress
TranscriptomicsEffect of fluoxetine treatment on translational profiles of S100a10 cortical pyramidal cells
Molecular phenotyping of cell types and neural circuits underlying pathological neuropsychiatric conditions and their responses to therapy provides one avenue for the development of more specific and effective treatments. In this study, we identify a cell population in the cerebral cortex that shows...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-35761 | biostudies-arrayexpress
TranscriptomicsEffect of fluoxetine treatment on translational profiles of Glt25d2 cortical pyramidal cells
Molecular phenotyping of cell types and neural circuits underlying pathological neuropsychiatric conditions and their responses to therapy provides one avenue for the development of more specific and effective treatments. In this study, we identify a cell population in the cerebral cortex that shows...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-35763 | biostudies-arrayexpress
TranscriptomicsEffect of fluoxetine treatment on translational profiles of S100a10 cortical pyramidal cells in p11 KOs
Molecular phenotyping of cell types and neural circuits underlying pathological neuropsychiatric conditions and their responses to therapy provides one avenue for the development of more specific and effective treatments. In this study, we identify a cell population in the cerebral cortex that shows...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-35765 | biostudies-arrayexpress
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