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ProteomicsIdentification and characterization of a ribosome receptor for starvation-induced ribophagy
The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1, and is associated with human disease. Here, we performed quantitative proteomic analyses of lysosomes rapidly isolated using the LysoIP method and find that nutrient levels and mTOR dynamically modulate...
ORGANISM(S): Homo sapiens (Human) 
2018-06-21 | PXD009084 | Pride
Lysosome Ribophagy Mtor 
ProteomicsA novel labelling strategy enables spatial resolution of metastatic niche cellular composition and uncovers lung stem cell activity proximal to breast cancer
Cancer cell behaviour is strongly influenced by the surrounding cellular environment, making the characterization of the local tumour microenvironment (or niche) a fundamental question in tumour biology. To date, a direct investigation of the early cellular changes induced by metastatic cells within...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-21 | PXD010597 | Pride
Metastasis Lung Tumour microenvironment 
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