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MetabolomicsReal-world neonicotinoid mixture exposure reveals synergistic cytotoxicity and divergent pathway vulnerabilities in human cell lines

In this study, five human cell lines (A2780, Chang liver, HEK293T, HeLa, and HepG2) were used as models and exposed to mixtures of neonicotinoids (NEOs) and their metabolites. The mixture concentrations were prepared based on human biomonitoring data to reflect the actual detected levels of NEOs ...

2026-06-22 | MTBLS13896 | MetaboLights
ProteomicsFaundez Comparison of 2 Cell lines (Hek and Hep)
Comparison of 2 cell lines by TMT fractionation mass spectrometry
ORGANISM(S): Homo sapiens (Human) 
2023-05-31 | PXD038974 | Pride
Hek and hep cells lines 
TranscriptomicsMiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2.2.15 cells.
Deficient DNA repair capacity is associated with genetic lesions accumulation and susceptibility to carcinogenesis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate various cellular pathways including DNA repair. Here we hypothesized that the existence of HBV products may interfere with ce...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-27561 | biostudies-arrayexpress
TranscriptomicsTranscriptome of HEK293 cells stably knockdown for the BAHD1 gene with a shRNA
Comparison of gene expression profile of HEK293 cells stably expressing a shRNA control (SilX-CT) or a shRNA against BAHD1 (SilX-BAHD1) We used microarrays to identify the repertoire of genes differentially expressed upon knockdown of the chromatin repressor BAHD1 in human HEK293 cells.
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-53284 | biostudies-arrayexpress
TranscriptomicsAnalysis of transcripts in PNA-A(15) oligo treated human HEK-293 cells
Mononucleotide A and T repeats are abundant in human genome. Many of A repeats are bound by Argonaute proteins (AGOs). To evaluate the role of AGOs and A repeats in gene regulation, HEK293 cells were treated with 8-amino-3,6-dioxaoctanoic acid added peptide nucleic acid (PNA) AAAAAAAAAAAAAAA oligo (...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-43185 | biostudies-arrayexpress
TranscriptomicsExpression profiling of host genes modulated by Epstein-Barr virus (EBV) Rta in HEK293 cells
EBV Rta is a transcriptional activator that functions to disrupt EBV latency in cells of epithelial origin. This series of experiment is to identify host genes that are moduated by the expression of doxycycline-inducible EBV Rta in HEK293 cells. Designations for the pooled EBV Rta inducible cell lin...
ORGANISM(S): Homo sapiens 
2011-05-22 | E-GEOD-24585 | biostudies-arrayexpress
TranscriptomicsAberrantly microRNA profiling in cancerous hepatocytes versus normal primary hepatocytes
MicroRNAs is a rapidly expanding area expected to change the way in which diseases will be diagnosed, treated and monitored in the future. Hepatocellular carcinoma (HCC) shows a rising incidence with high mortality but lack of effective targeted therapies. We identified the aberrantly expressed miRN...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-20077 | biostudies-arrayexpress
TranscriptomicsHepatitis C virus-induced expression profiling of Hepatic and non-hepatic cancer cell lines.
To facilitate accurate measurement of the relative expression levels in Hepatitis C virus infection, we carried out in four human cancer cell lines derived from Hepatic (Hec3B; human hepatoma and Huh7; human hepatocellular carcinoma) or nonhepatic (Hec1B; human endometrial and 293T;human embryonic k...
ORGANISM(S): Homo sapiens 
2012-05-20 | E-GEOD-32886 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP: QKI data
To assess whether the transcripts identified by PAR-CLIP are regulated by the RNA-binding protein (RBP) Quaking (QKI), we analyzed the mRNA levels of mock-transfected and QKI-specific siRNA-transfected cells with microarrays. Transcripts crosslinked to QKI were significantly upregulated upon siRNA t...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21574 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP: miRNA inhibition data
To obtain evidence that Argonaute (AGO) crosslink-centered regions (CCRs) indeed contain functional miRNA-binding sites, we blocked 25 of the most abundant miRNAs in HEK 293 cells (Figure 5C of PMID 20371350) by transfection of a cocktail of 2'-O-methyl-modified antisense oligoribonucleotides and mo...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21577 | biostudies-arrayexpress
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