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ProteomicsmiR-1307-5p counteracts breast cancer angiogenesis and metastasis
MiRNAs have been shown to alter both protein expression and secretion in different cellular contexts. By combining in vitro, in vivo and in silico techniques, we demonstrated that overexpression of pre-miR-1307 reduced the ability of breast cancer cells to induce endothelial cell sprouting and angio...
ORGANISM(S): Homo sapiens (Human) 
2024-12-11 | PXD041087 | Pride
Breast cancer Cell culture supernatant Dia Mda-mb-231 Sp3 Mir-1307 Human Secretome 
ProteomicsHuman MDA-MB-231 breast cancer cells overexpressing miR-183-5p and its isomiRs
Overexpression of miR-183-5p|+2, but not of the other two isomiRs |0 and |+1, was observed to reduce cell cycle and cell proliferation in different triple-negative breast cancer cell lines. Therefore, we hypothesized that the |+2 isoform has targets distinct from the other two isoforms. To test this...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD026763 | Pride
Human Breast cancer Mir-183-5p Mirna Mda-mb-231 
ProteomicsPAK1 activation as a common mechanism of endocrine therapy resistance in luminal A breast cancer models
Breast cancer is a highly heterogeneous disease, representing the most frequent malignancy and the second leading cause of cancer-related mortality in women worldwide. Among breast cancer subtypes, estrogen receptor-positive (ER+) tumors are often treated with endocrine therapies such as Tamoxifen o...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD063393 | Pride
Endocrine therapy Breast cancer Therapy resistance Phosphoproteomics 
ProteomicsPhosphoproteomics measurement of clonal endocrine therapy sensitive and resistant breast cancer populations
Around two thirds of breast tumors are characterized by the expression of estrogen receptor α and are therapeutically treated by blocking estrogen signaling. First line endocrine therapeutics are Tamoxifen which displaces estrogen form its receptor preventing receptor activation and aromatase inhibi...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040478 | Pride
Phosphoproteomics Clonal deconvolution Breast cancer Therapy resistance 
UnknownSpatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring.
Not available
S-EPMC6973045 | biostudies-literature
UnknownElective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries.
Not available
S-EPMC9621702 | biostudies-literature
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