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GenomicsHELZ2 regulates APOB mRNA stability to modulate fatty liver disease and atherosclerosis
HELZ2 regulates APOB mRNA stability to modulate fatty liver disease and atherosclerosis
PRJNA1336520 | ENA
OtherHELZ2 regulates APOB mRNA stability to modulate fatty liver disease and atherosclerosis
Background: Apolipoprotein B (APOB) is essential for lipoprotein assembly and secretion and plays a central role in the development of cardiovascular disease and metabolic dysfunction-associated steatotic liver disease (MASLD). While APOB protein degradation during very low-density lipoprotein (VLDL...
ORGANISM(S): Mus musculus 
2026-01-21 | GSE309603 | GEO
ProteomicsHELZ2: a new, interferon-regulated, human 3’-5’ exoribonuclease of the RNB family is expressed from a non-canonical initiation codon
Proteins containing a RNB domain, originally identified in E. coli RNase II, are widely present throughout the tree of life. Many RNB proteins are endowed with 3’-5’ exoribonucleolytic activity but some have lost catalytic function during evolution. Database searches identified a new RNB domain cont...
ORGANISM(S): Homo sapiens (Human) 
2023-08-18 | PXD040351 | Pride
Helicase Interferon Virus Nuclease Rna decay Translation initiation Double-stranded rna Transposons 
UnknownHELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus.
Not available
S-EPMC5316548 | biostudies-literature
UnknownHELZ2 Regulates ApoB mRNA Stability to Modulate Fatty Liver Disease and Atherosclerosis.
Not available
S-EPMC12810863 | biostudies-literature
UnknownHELZ2: a new, interferon-regulated, human 3'-5' exoribonuclease of the RNB family is expressed from a non-canonical initiation codon.
Not available
S-EPMC10516660 | biostudies-literature
UnknownThe interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction.
Not available
S-EPMC9839780 | biostudies-literature
UnknownA rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han.
Not available
S-EPMC4819269 | biostudies-literature
UnknownMutations in KIAA1109, CACNA1C, BSN, AKAP13, CELSR2, and HELZ2 Are Associated With the Prognosis in Endometrial Cancer.
Not available
S-EPMC6854026 | biostudies-literature
TranscriptomicsInfluence of varying dietary ratios of ω6 to ω3 fatty acids on the hepatic global gene expression, and association with phenotypic traits (growth, somatic indices and tissue lipid composition) in Atlantic salmon (Salmo salar)
The present study investigated the influence of plant-based diets (12-week exposure) with varying ω6:ω3 (0.4–2.7) on the hepatic transcriptome of Atlantic salmon, and the relationships with tissue (i.e. liver, muscle) lipid composition, and growth performance. The current microarray study identified...
ORGANISM(S): Salmo salar 
2021-06-23 | GSE139418 | GEO
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