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ProteomicsDifferential expression of proteins in hematopoietic stem/progenitor cells lacking the Cullin-5 protein
Cullin proteins are scaffolds that coordinate assembly of cullin-RING E3 ubiquitin (Ub) ligases (CRL), complexes that control post-translational ubiquitin modification and degradation of cellular proteins. Cullin-5 (Cul5) coordinates assembly of CRL complexes containing the RING E3 ligase Rbx1/2, th...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-26 | PXD051430 | Pride
Cullin-5 Hematopietic stem and progenitor cells  lsk cells 
TranscriptomicsEffect of loss of Gfi1b on hematopietic stem cells
Using Gfi1b conditional mice, deletion of gfi1b in the hematopietic system was induced by injecting MxCre tg Gfi1bfl/fl mice with pIpC. 30 days after injection, Cd150 pos, Cd 48 neg, Lin neg Sca and c-kit pos stem cells were sortrted from Gfi1bfl/fl and Mxcre tg Gfi1bfl/fl mice and analysed. We used...
ORGANISM(S): Mus musculus 
2010-09-03 | E-GEOD-20655 | biostudies-arrayexpress
TranscriptomicsGene expression in WT and Ikaros-deficient LSK cells
The Ikaros zink finger transcription factor is a critical regulator of the hematopietic system, and plays an important role in the regulation of the development and function of several blood cell lineages. We used microarrays to characterize how Ikaros deficieny affects global transcription in the h...
ORGANISM(S): Mus musculus 
2015-11-03 | E-GEOD-61147 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of TFEB overexpression in LT-HSC, ST-HSC and MEP
Long-term hematopoietic stem cells (LT-HSC), Short-term hematopietic stem cells (ST-HSC) and Megakaryocyte-erythrocyte progenitors (MEP) were sorted from human cord blood and cultured overnight before transduction with lentivirus to overexpress GP91 (CTRL) or TFEB. Three (LT-HSC ans ST-HSC) or six (...
EGAS00001004969 | EGA
GenomicsThe analysis of gene expression in hematopietic stem/progenitor cells (HSPCs LSK cells, Lineage-, c-kit+, Sca-1+) from diabetic/nondiabetic mice.
The analysis of gene expression in hematopietic stem/progenitor cells (HSPCs LSK cells, Lineage-, c-kit+, Sca-1+) from diabetic/nondiabetic mice.
PRJNA481025 | ENA
TranscriptomicsGene expression in WT and Ikaros-deficient LSK cells
The Ikaros zink finger transcription factor is a critical regulator of the hematopietic system, and plays an important role in the regulation of the development and function of several blood cell lineages. We used microarrays to characterize how Ikaros deficieny affects global transcription in the h...
ORGANISM(S): Mus musculus 
2015-11-03 | GSE61147 | GEO
TranscriptomicsHematopietic system high resolution transcriptome
Recent advances in high density oligonucleotides microarray technology have generated solutions for molecular profiling of human samples at an unprecedented resolution. We mapped whole blood RNA from healthy volunteers and CD34+ collected by cytapheresis from patients to Exon ST 1.0 microarray probi...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-10480 | biostudies-arrayexpress
TranscriptomicsEarly Events in Hematopoietic Cells Reprogramming into iPS Cells
Fibroblasts are the most commonly used model in probing the complex process of somatic reprogramming. Although hematopoietic cells represents a more  convenient and accesible/ or “an excellent alternative” starting cell type, the molecular mechanisms in hematopoietic reprogramming are poorly defined...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-54462 | biostudies-arrayexpress
UnknownGene therapy for sickle cell disease: An update.
Not available
S-EPMC6123269 | biostudies-literature
GenomicsMus musculus
Gene expression in WT and Ikaros-deficient LSK cells
PRJNA260352 | ENA
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