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OtherInflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.
Data from ProteomeXchange, PXD ID: PXD001500. Experiment: IFNAR_KO_Prog_78a, file: 120503_JH_IFNAR_KO_Prog_78a_10.mzml. Published as part of Cell Stem Cell. 2015 Aug 19. pii: S1934-5909(15)00306-9 . From the Abstract: {{i}} ... Here, we report that the phenotypic hematopoietic stem cell (HSC) compa...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310023393 | GPMDB
Resource Reanalysis 
TranscriptomicsTranscription profiling of bone marrow hematopoietic stem cells and myeloid progenitors from mice with conditional deletion of Forkhead O (FoxO) family of transcription factors
To investigate the role of FoxO transcription factors as mediators of hematopoietic stem cell resistance to oxidative stress. Experiment Overall Design: Study the effect of the deficiency of FoxO1, FoxO3, and FoxO4 in murine bone marrow hematopoietic stem cells and myeloid progenitors on expression ...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6623 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis
mass spectrometry analysis of aged and adult hematopoietic stem cells, multipotent progenitors and oligopotent progenitors
ORGANISM(S): Mus musculus (Mouse) 
2021-07-24 | PXD017442 | Pride
Hematopoiesis Early blood progenitors Stem cells Hematopoietic stem cells Aging 
TranscriptomicsIdentification of STAT5 target genes in human CB HSC, CMP, GMP and MEP
CB CD34+ cells were isolated by Miltenyi miniMACS column. Cells were prestimulated in HPGM with 100 ng/ml KITL, FLT#L and TPO for 48 hrs. Cells were transduced with control MiNR1 or STAT5A-ER in three rounds over 48 hrs. Hematopoietic stem cells (HSCs), common myeloid progenitors (CMPs), granulocyte...
ORGANISM(S): Homo sapiens 
2011-01-22 | E-GEOD-26775 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of long-term hematopoietic stem cells from old and young mice to investigate the mechanisms of hematopoietic aging
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties...
ORGANISM(S): Mus musculus 
2007-12-19 | E-GEOD-4332 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of Hematopoietic Stem Cells during acute inflammation
Infections are associated with extensive consumption of blood platelets representing a high risk for health. How the hematopoietic system coordinates the rapid and efficient regeneration of this particular lineage during such stress scenarios remains unclear. Here we report that the phenotypic hemat...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-26 | PXD001500 | Pride
Lc-msms Mouse Hematopoietic stem cells 
ProteomicsSecretome Comparison of Mesenchymal Stromal Cells and Immature Osteoblasts
Osteoblasts are a key component of the endosteal hematopoietic stem cell (HSC) niche and have long been recognized with strong hematopoietic supporting activity. Osteoblast conditioned media (OCM) enhances the growth of hematopoietic progenitors in culture and modulate their engraftment activity. We...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-15 | MSV000088384 | MassIVE
TranscriptomicsExpression data for conditional Dnmt1knockout hematopoietic stem and progenitor cells
DNA methylation is essential for mammalian development and plays crucial roles in a variety of biological processes. The DNA methyltransferase Dnmt1 serves to maintain parental cell methylation patterns on daughter DNA strands in mitotic cells, however, the precise role of Dnmt1 in regulation of qui...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15840 | biostudies-arrayexpress
GenomicsGenome-Wide DNA Methylation Profiles in Hematopoietic Stem and Progenitor Cells Reveal Over-Representation of ETS Transcription Factor Binding Sites
DNA methylation is an essential epigenetic mark that is required for normal development. Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment reveals that methylation is critical for hematopoietic differentiation. To better understand the role of DNA methylation in he...
ORGANISM(S): Mus musculus 
2012-06-01 | E-GEOD-38354 | biostudies-arrayexpress
TranscriptomicsERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation
To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were decreased in these mice. To define Erg downstream target genes in hematopoietic stem cells, we sorted...
ORGANISM(S): Mus musculus 
2015-09-21 | E-GEOD-69873 | biostudies-arrayexpress
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