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MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
MetabolomicsViral-Induced Heme Accumulation Subverts TLR4bb-Mediated Antiviral Immunity by Triggering Gut Microbiota Dysbiosis, Metabolic Dysregulation, and Ferroptosis

This study identifies grass carp TLR4bb as a crucial hub coordinating antiviral immunity with heme metabolism, redox balance, and gut microbiota during GCRV-II infection. While TLR4bb recruits TIRAP/MyD88/TRIF to activate IFN signaling against the virus, its synergy with heme and viral sensing tr...

2026-01-23 | MTBLS13755 | MetaboLights
TranscriptomicsGATA-1 and heme regulate the erythroid cell transcriptome.
Alas2 gene encodes the rate-limiting enzyme in heme biosynthesis. CRISPR/Cas9-mediated ablation of two Alas2 intronic cis-elements strongly reduced GATA-1-induced Alas2 transcription, heme biosynthesis, and GATA-1 regulation of other vital constituents of the erythroid cell transcriptome. Bypassing ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-74371 | biostudies-arrayexpress
TranscriptomicsHeme-based respiration of Leuconostoc gasicomitatum
Transcriptonal profiling of Leuconostoc gasicomitatum LMG18811T (wild type) grown in MRS medium with or without heme. Mutant LMG18811T::pSIP1333A (mutating cydB gene which is essential in the respiratory chain) grown in MRS with or without heme. Comparing mutant and wildtype with and without heme. ...
ORGANISM(S): Leuconostoc gasicomitatum LMG 18811 
2013-02-08 | E-GEOD-41281 | biostudies-arrayexpress
GenomicsHeme metabolism confronts urinary pathogens at the urothelium
Heme metabolism confronts urinary pathogens at the urothelium
PRJNA560373 | ENA
GenomicsControl of Renal Central Carbon Metabolism by Heme Oxygenase-1
Control of Renal Central Carbon Metabolism by Heme Oxygenase-1
PRJNA1033649 | ENA
GenomicsWhere Does the Heme Go? Unraveling Heme and Porphyrin Metabolism in Healthy and Oncogenic Human Livers
Where Does the Heme Go? Unraveling Heme and Porphyrin Metabolism in Healthy and Oncogenic Human Livers
PRJNA1117416 | ENA
ProteomicsPseudomonas aeruginosa Heme Metabolites Biliverdin IX and IX are Integral to Lifestyle Adaptations Associated with Chronic Infection
Pseudomonas aeruginosa is a versatile opportunistic pathogen requiring iron for its survival and virulence within the host. The ability to switch to heme as an iron source provides an advantage in chronic infection. We have recently shown the extracellular heme metabolites biliverdin IX (BVIX) and/o...
ORGANISM(S): Pseudomonas aeruginosa PABL056 
2024-01-19 | PXD045835 | Pride
Proteomics Metabolomics Type iv pili and chemotaxis Heme Biliverdin Pseudomonas aeruginosa 
TranscriptomicsTranscription profiling of S. cerevisiae response to the antifungal compound sampangine
Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analy...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-11 | E-GEOD-10073 | biostudies-arrayexpress
TranscriptomicsDietary heme mediated PPARM-NM-1 activation does not affect the heme-induced epithelial hyperproliferation and hyperplasia in mouse colon
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is overcompensated by hyperproliferation and hyperplasia of crypt cells. Transcriptome anal...
ORGANISM(S): Mus musculus 
2012-08-22 | E-GEOD-37006 | biostudies-arrayexpress
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