Rapid, deep, and sustained systemic ketosis was achieved using an orally administered ketone ester (KE: 3.0 mg/g body weight of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate; DeltaG® Ketone Ester, TΔS® Ltd, Oxfordshire, UK) compared with control (0.9% NaCl) prior to permanent middle cerebral artery oc...