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UnknownIn vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
Not available
S-EPMC2662067 | biostudies-literature
TranscriptomicsGlobal analysis of alternative splicing regulation by insulin and wingless signalling in Drosophila cells
Background: Despite the prevalence and biological relevance of both signalling pathways and alternative pre-mRNA splicing, our knowledge of how intracellular signalling impacts on alternative splicing regulation remains fragmentary. We report a genome-wide analysis of changes in alternative splicing...
ORGANISM(S): Drosophila melanogaster 
2010-05-06 | E-GEOD-14085 | biostudies-arrayexpress
TranscriptomicsExpression Data from chemical induced tumors obtained from NDR1+/+, NDR1+/- and NDR1-/- mice
Loss and heterozygosity for NDR1 predisposes mice to T-cell lymphoma development. To analyze mechanisms of tumor development in these mice chemically (ENU)-induced tumors were collected and RNA was extracted. Tumors were collected from mice upon tumor development or 9 months after ENU treatment. Tum...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-21902 | biostudies-arrayexpress
TranscriptomicsExpression data from U373 cells expressing EGFP, MAML1-dn and DTX1-myc
Glioblastoma multiforme (GBM) is the most malignant and most common tumor of the central nervous system characterized by rapid growth and extensive tissue infiltration. GBM results in more years of life lost than any other cancer type. Notch signaling has been implicated in GBM pathogenesis through ...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-22772 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human gliomas and human glioblastoma cell lines
To identify signaling pathways that are differentially regulated in human gliomas, a microarray analysis on 30 brain tumor samples (12 primary glioblastomas (GBM), 3 secondary glioblastomas (GBM-2), 8 astrocytomas (Astro) and 7 oligodendrogliomas (Oligo)) and on 5 glioblastoma cell lines (LN018, LN...
ORGANISM(S): Homo sapiens 
2011-03-18 | E-GEOD-15824 | biostudies-arrayexpress
UnknownIntramolecular and intermolecular interactions of protein kinase B define its activation in vivo.
Not available
S-EPMC1845162 | biostudies-literature
UnknownThe ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.
Not available
S-EPMC535089 | biostudies-literature
UnknownDifferential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
Not available
S-EPMC2937529 | biostudies-literature
UnknownDifferential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.
Not available
S-EPMC2812230 | biostudies-literature
UnknownExpression data from U373 cells expressing EGFP, MAML1-dn and DTX1-myc
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-22772 | biostudies-other
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