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ProteomicsWNK1 signalling regulates amino acid transport and mTORC1 activity to sustain AML growth
The lack of curative therapies for acute myeloid leukaemia (AML) remains an ongoing challenge despite recent advances in the understanding of the molecular basis of the disease. Here we identify the WNK1-OXSR1/STK39 pathway as a previously uncharacterised dependency in AML. We show that genetic depl...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-02 | PXD041902 | Pride
Wnk1 Phosphoproteomics Aml Mtor 
ProteomicsAnatomic position determines oncogenic specificity in melanoma
Oncogenic alterations to DNA are not transforming in all cellular contexts. This may be due to pre-existing transcriptional programs in the cell of origin. Here, we define anatomic position as a major determinant of why cells respond to specific oncogenes. Cutaneous melanoma arises throughout the bo...
ORGANISM(S): Homo sapiens (Human) 
2022-01-12 | PXD027968 | Pride
Ip-ms Human Melanoma 
ProteomicsHistone H3 lysine 4 trimethylation regulates RNA polymerase II promoter-proximal pause-release
Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites and proposed to regulate transcription initiation. However, redundant functions of the H3K4 SET1/COMPASS methyltransferase complexes complicate elucidation of the specific role of H3K4me3 in transcriptiona...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-14 | PXD028858 | Pride
Histone Rna polymerase ii 
ProteomicsCandidate disease progression biomarkers in AD
Cross-sectional and longitudinal Analysis of CSF from controls and cases with AD
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-15 | MSV000079192 | MassIVE
UnknownVariation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic.
Not available
S-EPMC8217146 | biostudies-literature
UnknownEffectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021.
Not available
S-EPMC9113447 | biostudies-literature
UnknownAssessment of Symptom, Disability, and Financial Trajectories in Patients Hospitalized for COVID-19 at 6 Months.
Not available
S-EPMC9929698 | biostudies-literature
UnknownEffect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.
Not available
S-EPMC10214036 | biostudies-literature
UnknownEfficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients: A Randomized Clinical Trial.
Not available
S-EPMC8669605 | biostudies-literature
UnknownClopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Not available
S-EPMC6193486 | biostudies-literature
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