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We report the comprehensive sequencing of small RNA libraries created from different developmental stages of the basal chordate, Ciona intestinalis. Surprisingly, half of the identified miRNA loci encode not two, but up to four distinct small RNAs. These additional RNAs, termed M-bM-^@M-^\moRsM-bM-...
ORGANISM(S): Drosophila melanogaster 
Recent years have seen a tremendous increase in the study of extracellular vesicles (EV) geared towards biological understanding, diagnostics and therapy. The interpretation of EV data however remains challenging owing to the complexity of biofluids and the technical variability that are introduced ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD010269 | Pride
The histone modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the activation state of genes controlling pluripotency, lineage commitment, and cell differentiation. Long non-coding RNAs (lncRNAs) can bind to either complex, and some have been shown to act as modulators of PRC2 o...
ORGANISM(S): Mus musculus 
Separating lipid-carrying particles from body fluids is challenging and complicates studies of extracellular vesicles (EV) and lipoprotein particles (LPP) as disease biomarkers. In this study, we assess the biomolecular composition and dynamics of systemically circulating matched EV and LPP by analy...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023001 | Pride
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