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Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

The efficacy of immunotherapy against colorectal cancer (CRC) is impaired by insufficient immune cell recruitment into the tumor microenvironment. Our study shows that targeting circDNA2v, a circular RNA commonly overexpressed in CRC, can be exploited to elicit cytotoxic T-cell recruitment. CircDNA2...
ORGANISM(S): Homo Sapiens 
2024-04-11 | PXD051359 |
Extracellular matrix (ECM) disorder was considered as the result of fibrosis, but it is recently recognized that fibrotic ECM activates a profibrotic positive feedback loop and contributes to development of fibrosis. Versican, an ECM component, participates in cell-ECM interaction and ECM regenerati...
ORGANISM(S): Homo Sapiens 
2026-01-15 | PXD073100 |
In this study, we established a type 2 diabetes model in C57BL/6 mice through high-fat diet induction and STZ injection. Based on this animal model, we simulated clinically common hard-to-heal chronic diabetic skin wounds by implanting a mixed bacterial fluid, including Methicillin-resistant Staphyl...
ORGANISM(S): Mus Musculus 
2023-08-29 | PXD044920 |
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