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ProteomicsProteomics and network analyses reveals inhibition of Akt-mTOR signaling in CD4+ T cells by Mycobacterium tuberculosis Mannose-capped Lipoarabinomannan
CD4+ T cells have a central role in controlling Mtb infection (1). Despite immune control, Mtb persists by interfering with macrophage and T cell function, allowing for pathogen survival. Our group has demonstrated direct and indirect inhibition of CD4+ T cell activation by different Mtb molecules i...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-05 | PXD004164 | Pride
Lc/ms/ms Mycobacterium tuberculosis mannose-capped lipoarabinomannan Pathway analysis Label free proteomics 
TranscriptomicsTranscription profiling of human blood leukocytes and T-cells
Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for medicine’s future. Patients with injury severe enough to develop multiple organ dysfunction syndrome (MODS) are known to have multiple immune derangements, including T-cell apoptosis an...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5580 | biostudies-arrayexpress
TranscriptomicsCD4+ T cell gene expression in B6 vs B6.Sle1c2 mice
Sle1c is a sublocus of the NZM2410-derived Sle1 major susceptibility locus. We have previously shown that Sle1c contributes to lupus pathogenesis by conferring CD4+ T cell-intrinsic hyperactivation and increased susceptibility to chronic graft-versus-host disease (cGVHD) that mapped to the centrome...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-31702 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse D10.G4.1 T-cells treated with neuromedin U for different length of time to study the effect of neuromedin on gene expression in T cells.
Effects of Neuromedin-U on gene expression in mouse D10.G4.1 T-cells natively expressing the GPCR Axor13
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-1791 | biostudies-arrayexpress
UnknownAXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells.
Not available
S-EPMC10530462 | biostudies-literature
UnknownIs CD19-directed chimeric antigen receptor T cell therapy a smart strategy to combat central nervous system lymphoma?
Not available
S-EPMC9850100 | biostudies-literature
UnknownLeukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia.
Not available
S-EPMC8058445 | biostudies-literature
ModelsWodarz2007 - Cytomegalovirus infection model with cytotoxic T lymphocyte response
This a model from the article: Dynamics of killer T cell inflation in viral infections. Wodarz D, Sierro S, Klenerman P. J R Soc Interface 2007 Jun 22;4(14):533-43 17251133 , Abstract: Upon acute viral in...
2024-09-02 | BIOMD0000000687 | BioModels
Unknownβ-Catenin in Dendritic Cells Negatively Regulates CD8 T Cell Immune Responses through the Immune Checkpoint Molecule Tim-3.
Not available
S-EPMC11125945 | biostudies-literature
UnknownDOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory.
Not available
S-EPMC3517112 | biostudies-literature
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