Transcription profiling of human blood leukocytes and T-cells

ABSTRACT: Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for medicine’s future. Patients with injury severe enough to develop multiple organ dysfunction syndrome (MODS) are known to have multiple immune derangements, including T-cell apoptosis and anergy combined with depressed monocyte antigen presentation. Genome-wide expression analysis of highly-enriched circulating leukocyte subpopulations, combined with cell-specific pathway analyses, offers a previously unavailable opportunity to discover novel leukocyte regulatory networks in critically injured patients. Severe injury induced significant changes in the T-cell, monocyte, and total leukocyte transcriptome, with only 12% of these genomic changes common to all three cell populatio

ORGANISM(S): Homo sapiens

SUBMITTER: IDDC Inflammation the Host Response to Injury 

PROVIDER: E-GEOD-5580 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress