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TranscriptomicsTranscription profiling of Dictyostelium discoides mutant cell type aspidocyte induced by heavy meatals and antibiotics
We describe the serendipitous discovery and first characterization of a new resistant cell type from Dictyostelium, which we propose to call the aspidocyte (aspida: Greek for shield). These cells are induced from amoebae by a range of toxins including heavy metals and antibiotics, and were first det...
ORGANISM(S): Dictyostelium discoideum 
2007-02-06 | E-SGRP-5 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte-derived macrophages infected with HIV-1 or uninfected and stimulated with E. coli lipopolysaccharide
Whole genome expression profiling of HIV-1 infected and uninfected monocyte-derived macrophages
ORGANISM(S): Homo sapiens 
2009-01-01 | E-MEXP-1904 | biostudies-arrayexpress
TranscriptomicsMolecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy
Patients with high-risk localized prostate cancer (tumor-node-metastasis ≥ T2b or prostate-specific antigen ≥ 15 ng/mL or Gleason glade ≥ 4+3) were enrolled into a phase II clinical trial of neoadjuvant chemotherapy with docetaxel and mitoxantrone followed by prostatectomy. Pretreatment prostate tis...
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-40434 | biostudies-arrayexpress
TranscriptomicsMetastatic Cascade is Reflected in the Gene Expression of Metastatic Canine Mammary Carcinomas Similar to Human Breast Cancer
Proliferation, dedifferentiation, loss of cell-cell contacts and angiogenesis are among the first steps of the metastasis cascade. The complex molecular pathways associated with these events in canine mammary tumors are mostly unknown and the value of this spontaneous canine tumor as a comparative m...
ORGANISM(S): Canis lupus familiaris 
2010-12-01 | E-GEOD-22516 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte-derived macrophages infected with HIV-1 or stimulated with interferon-beta, interferon-gamma or lipopolysaccharide
Transcriptional profiling of HIV-1 infected and that of IFNbeta, IFNgamma or LPS stimulated human monocyte derived macrophages.
ORGANISM(S): Homo sapiens 
2009-09-01 | E-MEXP-2032 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of in vivo immune responses to mycobacteria using the tuberculin skin test
Transcriptional profiling of biopsies from tuberculin skin test sites was performed to investigate the interaction of complex cellular and molecular networks at the interface between innate and adaptive immunity which coordinate anti-mycobacterial responses in vivo.
ORGANISM(S): Homo sapiens 
2012-05-13 | E-TABM-1157 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dermal endothelial cells treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h
Cells were treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h at 37°C with 5 % CO2 and 95 % humidity..
ORGANISM(S): Homo sapiens 
2007-04-25 | E-RZPD-14 | biostudies-arrayexpress
TranscriptomicsGGI: a potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1-98 trial
Background: We have previously shown that the Gene expression Grade Index (GGI) was able to identify two subtypes of estrogen receptor (ER)-positive tumors that were associated with statistically distinct clinical outcomes in both untreated and tamoxifen-treated patients. Here, we aim to investigate...
ORGANISM(S): Homo sapiens 
2009-07-09 | E-GEOD-16391 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish development
We are performing microarray experiments for expression profiling of zebrafish embryogenesis, both as a baseline for future analysis of mutant and other conditions and to validate our microarray technology. For our purpose we used the Affymetrix zebrafish array which contains approximately 15,000 g...
ORGANISM(S): Danio rerio 
2005-08-18 | E-TABM-33 | biostudies-arrayexpress
TranscriptomicsEarly and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus.
This study revealed important similarities but also critical differences between the H5N1 and 1918-reassortant viruses, highlighting aspects of the host–pathogen interface caused by highly virulent influenza viruses. Animals assigned to 4 experimental groups (n = 8) matched for age, weight, and sex,...
ORGANISM(S): Macaca fascicularis 
2011-11-01 | E-GEOD-33351 | biostudies-arrayexpress
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