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ProteomicsUsing isotopically labeled calibrants to quantify Heparan sulfate
This dataset contains the all the mass spectral data related to this research.
ORGANISM(S): Quantification Analysis Of Hs Using Lc-msms 
2020-06-11 | MSV000085577 | MassIVE
TranscriptomicsHeparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15974 | biostudies-arrayexpress
ProteomicsStructure of the human heparan sulfate polymerase complex EXT1-EXT2
Heparan sulfates are complex polysaccharides that mediate the interaction with a broad range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is catalyzed by the bi-functional glycosyltransferases EXT1 and EXT2, which generate the glycan backbone consisting of repea...
ORGANISM(S): Homo sapiens (Human) 
2022-12-09 | PXD034871 | Pride
Ext2 Ext1 Cell surface Nanolc-ms/ms Heparan sulfates 
GenomicsHeparan sulfate-associated RNA
Heparan sulfate-associated RNA identification enabled by SCOOPS
PRJEB88260 | ENA
TranscriptomicsExamine differential expression of sulf-1 and sulf-2, enzymes involved in heparan sulfate biosynthesis
Our specific aim is to examine differential expression of sulf-1 and sulf-2, enzymes involved in heparan sulfate biosynthesis, as well as Wnt ligands and Wnt signaling mediators during corneal wound healing using a mouse corneal scratch model. The specific structural features of heparan sulfate unde...
ORGANISM(S): Mus musculus 
2011-04-29 | E-GEOD-28931 | biostudies-arrayexpress
ProteomicsGalectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatase Sulf-2
Human extracellular 6-O-endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6-O sulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of Sulf-2 in different cancers has been documented and we have ...
ORGANISM(S): Homo Sapiens (human) 
2024-04-25 | PXD051711 | JPOST Repository
ProteomicsGalectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2
Human extracellular 6-O-endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6-O sulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of Sulf-2 in different cancers has been documented and we have ...
ORGANISM(S): Homo Sapiens (human) 
2024-01-20 | PXD048713 | JPOST Repository
ProteomicsProteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin binding protein
Animal cells express heparan sulfate proteoglycans that perform many important cellular functions by way of heparan sulfate-protein interactions. The identification of membrane heparan-sulfate binding proteins is challenging because of their low abundance and the need for extensive enrichment. Here,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-01-09 | MSV000084782 | MassIVE
ModelsGiantsosAdams2013 - Growth of glycocalyx under static conditions
Giantsos-Adams2013 - Growth of glycocalyx under static conditions This model is described in the article: Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation. Giantsos-Adams KM, Koo AJ, Song...
2024-09-02 | BIOMD0000000830 | BioModels
ModelsGiantsos-Adams2013 - Growth of glycocalyx under static conditions
Giantsos-Adams2013 - Growth of glycocalyx under static conditions This model is described in the article: Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation. Giantsos-Adams KM, Koo AJ, Song S, Sakai J, Sankaran J, Shin JH, Garcia-Carde...
2016-09-28 | MODEL1609100001 | BioModels
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