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TranscriptomicsZygotic expression of Exostosin1 (Ext1) is required for establishment of dorsal-ventral pattern in Xenopus
Exostosin 1 (Ext1) is a glycosyltransferase involved in the biosynthesis of the extracellular matrix Heparan Sulfate Proteoglycan (HSPG). Knockdown of Ext1 caused gastrulation defects and formation of an abnormal body axis. Since ext1 has been implicated as an indirect contributor to multiple signal...
ORGANISM(S): Xenopus laevis 
2013-10-23 | E-GEOD-51562 | biostudies-arrayexpress
ProteomicsStructure of the human heparan sulfate polymerase complex EXT1-EXT2
Heparan sulfates are complex polysaccharides that mediate the interaction with a broad range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is catalyzed by the bi-functional glycosyltransferases EXT1 and EXT2, which generate the glycan backbone consisting of repea...
ORGANISM(S): Homo sapiens (Human) 
2022-12-09 | PXD034871 | Pride
Ext2 Ext1 Cell surface Nanolc-ms/ms Heparan sulfates 
TranscriptomicsTranscription profiling by microarray of A549 cells and Ext1 knock out or wild type mouse embryonic fibroblast cells co-cultured as spheroids
Determine differentially expressed human genes in A549 tumors when co-cultured in spheroids with mouse fibroblast harbouring a mutation in the heparan sulphate elongation enzyme Ext1 compared to corresponding wild-type fibroblast/A549-containing spheroids.
ORGANISM(S): Homo sapiens 
2018-04-04 | E-MTAB-5874 | biostudies-arrayexpress
ProteomicsEXTL3ΔN purification from EXT1 CRISPR HEK
Experiment for label-free quantification of contaminants in preparations of EXTL3ΔN from transgenic HEK cells. EXTL3ΔN-expressing HEK cells were not untreated (untransfected / Batch C), treated with a set of CRISPR control plasmids (CRISPR control / Batch A), or treated with a set of CRISPR plasmids...
ORGANISM(S): Homo sapiens (Human) 
2022-07-12 | PXD032144 | Pride
Extl3δn Ext1 Extl3 Hek 
GenomicsTranscriptome analysis of HeLa cells knocked down for EXT1 or FBXW7 gene expression
Transcriptome analysis of HeLa cells knocked down for EXT1 or FBXW7 gene expression
PRJNA574199 | ENA
TranscriptomicsZygotic expression of Exostosin1 (Ext1) is required for establishment of dorsal-ventral pattern in Xenopus
Exostosin 1 (Ext1) is a glycosyltransferase involved in the biosynthesis of the extracellular matrix Heparan Sulfate Proteoglycan (HSPG). Knockdown of Ext1 caused gastrulation defects and formation of an abnormal body axis. Since ext1 has been implicated as an indirect contributor to multiple signal...
ORGANISM(S): Xenopus laevis 
2013-10-23 | GSE51562 | GEO
GenomicsWhole transcriptome profiling of Wildtype and EXT1-/- human embryonic stem cells by RNA-Seq
Whole transcriptome profiling of Wildtype and EXT1-/- human embryonic stem cells by RNA-Seq
PRJNA602525 | ENA
TranscriptomicsWhole transcriptome profiling of Wildtype and EXT1-/- human embryonic stem cells by RNA-Seq
Purpose: The goals of this study are to identify whole transcriptomic changes between undifferentiated wildtype (H9 cell line) and undifferentiated EXT1-/- human embryonic stem cells using RNA-seq. Total RNA extraction was performed on low passage number wildtype and EXT1-/- human embryonic stem cel...
ORGANISM(S): Homo sapiens 
2020-01-22 | GSE144025 | GEO
TranscriptomicsTranscriptome analysis of HeLa cells knocked down for EXT1 or FBXW7 gene expression
Exostosin-1 (EXT1) is an ER-resident glycosyltransferase known to polymerize heparan sulfate chain by sequential addition of glucuronic acid and N-acetylglucosamine molecules. This reaction results in heavily glycosylated proteoglycans (PG) at the plasma membrane, which form cell-type specific compl...
ORGANISM(S): Homo sapiens 
2020-09-25 | GSE138030 | GEO
TranscriptomicsEndothelial Ext1 Is Essential for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury
The endothelial glycocalyx (eGCX) heparan sulfate (HS) is essential for vascular barrier function and inflammation regulation. To elucidate the endothelial cell-autonomous role of the HS synthase Ext1, we generated endothelial-specific Ext1-deficient mice (Ext1flox/flox; VE-cadherin–Cre) and perform...
ORGANISM(S): Mus musculus 
2026-10-07 | GSE313973 | GEO
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