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MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15524 | MetaboLights
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
he Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and immu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD068793 | Pride
Hepatic cyp450 Preclinical model Nanopig Whole genome sequencing Proteomics 
MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15525 | MetaboLights
ProteomicsLong term effects of ethanol intake on the CYP450 enzyme system in the liver of AFLD rats
Alcoholic fatty liver disease (AFLD) is a liver disease closely related to long-term alcohol consumption. Although it is known that liver microsomal cytochrome P450 enzyme (CYP450) plays a crucial role in metabolizing alcohol and various exogenous compounds, the specific mechanism by which alcohol a...
ORGANISM(S): Mus Musculus 
2025-04-27 | PXD063375 |
ProteomicsProteomic Consequences of the Deletion of Cytochrome P450 (CYP450) Reductase in Mice
Microsomal cytochrome P450 (CYP450) reductase enzymes play a major role in drug and xenobiotic metabolism. Mice which are deficient in hepatic CYP450 reductase serve as excellent models in understanding CYP450 drug metabolism and alterations in the underlying biology. A reversed-phase nano-bore UPLC...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-26 | PXD024420 | Pride
Proteomics  cytochrome p450  lipid metabolism  bile acids  glutathione Tca cycle. 
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
The Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and imm...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD069209 | Pride
Nanopig Tissue Plasma Lc-msms 
UnknownCharacterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective.
Not available
S-EPMC6592956 | biostudies-literature
ProteomicsProteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bio-activation and detoxification
Hepatic organoids are a recent innovation in in vitro modelling. Initial studies suggest organoids better recapitulate the liver phenotype in vitro compared to pre-existing proliferative cell models. However, their propensity for drug metabolism and detoxification remains poorly characterised. A glo...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-03 | PXD017986 | Pride
Drug metabolising enzymes and transporters In vitro Organoid Hepatic phenotype 
UnknownCYP450 drug inducibility in NAFLD via an in vitro hepatic model: Understanding drug-drug interactions in the fatty liver.
Not available
S-EPMC8792443 | biostudies-literature
UnknownHuman Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications.
Not available
S-EPMC5225883 | biostudies-literature
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