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TranscriptomicsDeactivation of Hepatic Stellate Cells during Liver Fibrosis Resolution in Mice
Gene expression of mouse hepatic stellate cells was characterized under the following conditions: Quiescent (isolated from normal mouse liver) and reverted (isolated from mouse liver treated with 4 injections of carbontetrachloride followed by 45 day rest period) Affymetrix Mouse 1.0ST gene express...
ORGANISM(S): Mus musculus 
2014-05-05 | E-GEOD-38648 | biostudies-arrayexpress
TranscriptomicsProfiling of the transcriptome during culture-induced activation of rat hepatic stellate cells.
Gene expression was determined in primary rat hepatic stellate cells during the in vitro activation process in freshly isolated (4h), quiescent (1d), early activated (3d) and fully activated (7d) hepatic stellate cells. The cells were isolated from the liver using density centrifugation and cultured...
ORGANISM(S): Rattus norvegicus 
2017-10-23 | E-MTAB-5404 | biostudies-arrayexpress
TranscriptomicsExpression data from human hepatic stellate cell line LX2 treated with suberoylanilide hydroxamic acid (SAHA) or valproic acid (VPA)
Suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) are both histone deacetylases inhibitor (HDACi), and are able to attenuate the activation of hepatic stelllate cells. To explore the underlying molecular mechanisms, we performed gene expression profile analyses of human hepatic stellate...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-MTAB-3764 | biostudies-arrayexpress
ProteomicsHuman hepatic stellate cell-derived extracellular vesicles LC-MSMS
Activation and migration of hepatic stellate cells (HSCs) followed by matrix deposition are characteristics of liver fibrosis. Several studies have shown the importance of hepatocyte and endothelial cell-derived extracellular vesicles (EVs) in liver pathobiology. However, less is known about the rol...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD007258 | Pride
Lc-msms Hepatic stellate cells Extracellular vesicles Liver 
TranscriptomicsTranscriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in vitro
Hepatic stellate cells are involved in the development of hepatic fibrosis. We here perform transcriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in ...
ORGANISM(S): Mus musculus 
2019-04-07 | E-MTAB-7054 | biostudies-arrayexpress
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis serum+feces)

Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. dista...

2023-03-17 | MTBLS6728 | MetaboLights
TranscriptomicsTranscriptome of human liver cells and culture-activated hepatic stellate cells
The molecular determinants of a healthy human liver cell phenotype remain largely uncharacterized. In addition, the gene expression changes associated with activation of primary human hepatic stellate cells, a key event during fibrogenesis, remain poorly characterized. Here, we provide the transript...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-68000 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human growing and senescent activated hepatic stellate cells
Cellular senescence is an irreversible proliferative arrest and can be triggered in many cell types in response to diverse forms of cellular damage or stress. We used microarrays to compare gene expression profile between growing and senescent human activated hepatic stellate cells. Experiment Overa...
ORGANISM(S): Homo sapiens 
2008-08-29 | E-GEOD-11954 | biostudies-arrayexpress
TranscriptomicsIntegrative gene expression profiling analysis of human quiescent hepatic stellate cells
Unveiling the regulatory pathways maintaining hepatic stellate cells (HSC) in a quiescent (q) phenotype is essential to develop new therapeutic strategies to treat fibrogenic diseases. To uncover the miRNA-mRNAs regulatory interactions in qHSCs, HSCs were FACS-sorted from healthy livers and activate...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-67664 | biostudies-arrayexpress
TranscriptomicsGene expression profiling and secretome analysis differentiate Adult-Derived Human Liver Stem/progenitor Cells and human hepatic stellate cells
Adult-derived human liver stem/progenitor cells (ADHLSC) are obtained after primary culture of the liver parenchymal fraction. The cells are of fibroblastic morphology and exhibit a hepato-mesenchymal phenotype. Hepatic stellate cells (HSC) derived from the liver non-parenchymal fraction present a c...
ORGANISM(S): Homo sapiens 
2015-05-11 | E-GEOD-49995 | biostudies-arrayexpress
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