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MetabolomicsHepatocyte Differentiation Metabolism
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ORGANISM(S): Homo sapiens 
ST000837 | MetabolomicsWorkbench
MetabolomicsMetabolomics profiling (GC-MS and LC-MS) for time-course differentiation of pre-B cells-like (B3 cell line) under the controlled induction of the transcription factor Ikaros (STATegra Project)
The main goal of the project is to develop a new generation of bioinformatics resources for the integrative analysis of multiple types of 'omics data. These resources include both novel statistical methodologies as well as user-friendly software implementations. STATegra methods address many aspects...
2016-12-15 | MTBLS283 | MetaboLights
ProteomicsDetection of Dichlorvos Aducts in Hepatocyte Cell Line LC-MS/MS
Toxicity of dichlorvos (DDVP), an organophosphate (OP) pesticide, classically results from modification of the serine in the active sites of cholinesterases. However, DDVP also forms adducts on unrelated targets such as transferrin and albumin, suggesting that DDVP causes cellular perturbation by mo...
ORGANISM(S): Homo sapiens (Human) 
2014-07-31 | PXD001107 | Pride
Hepatocyte cell line Dichorvos Lc-ms/ms 
ProteomicsHuman Hepatocyte Proteome
Here we report a comprehensive proteomic analysis of purified human hepatocytes and a human hepatoma cell line HepG2. The complete dataset comprises 9,400 proteins and provides quantitative depiction of the proteomes of hepatocytes and HepG2 cells at the protein titer and copy number dimensions.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-07 | MSV000079562 | MassIVE
TranscriptomicsGene expression profile of human embryonic stem cell-derived hepatocyte-like cells
The differentiation of pluripotent stem cells to hepatocyte-like cells offers the perspective of unlimited supply of human hepatocytes. However, the degree of differentiation of hepatic-like cells (HLC) remains controversial. To obtain an unbiased characterization, we performed a transcriptomics st...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-MTAB-4442 | biostudies-arrayexpress
ProteomicsHuman Hepatocyte Proteome - In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes
Here we report a comprehensive proteomic analysis of purified human hepatocytes and a human hepatoma cell line HepG2. The complete dataset comprises 9,400 proteins and provides quantitative depiction of the proteomes of hepatocytes and HepG2 cells at the protein titer and copy number dimensions.
ORGANISM(S): Homo sapiens (Human) 
2016-01-26 | PXD001874 | Pride
Human hepatocyte 
TranscriptomicsTranscription profiling by array of human hepatic cells derived from foreskin fibroblast cell line and from embryonic stem cells.
Reprogrammed somatic cells offer a valuable source of pluripotent cells that have the potential to differentiate into many cells types and provide a new tool for regenerative medicine. In the present study we differentiated induced pluripotent stem cells (iPS cells) into hepatic cells. We first show...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-14897 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HNF1beta mutated vs wildtype embryonic kidney cell line HEK293 to identify potential HNF1beta target genes whose activity may be deregulated in human patients
Hepatocyte nuclear factor 1beta (HNF1beta, TCF2) is a tissue-specific transcription factor whose mutation in humans leads to renal cysts, genital malformations, pancreas atrophy and maturity onset diabetes of the young (MODY5). Furthermore, HNF1beta overexpression has been observed in clear cell can...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-3308 | biostudies-arrayexpress
TranscriptomicsGene expression profile of human embryonic stem cell-derived hepatocyte-like cells in matrigel and recombinant laminins
Stem cell derived somatic cells represent an unlimited resource for basic and translational science. While promising, there are significant hurdles that must be overcome. Our focus is on the generation of the major cell type of the human liver, the hepatocyte. Current protocols produce variable pop...
ORGANISM(S): Homo sapiens 
2016-01-18 | E-MTAB-3994 | biostudies-arrayexpress
TranscriptomicsExpression data of HGF/cMET pathway in prostate cancer DU145 cell line
DU145 prostate cancer cells were treated with 25 ng/ml hepatocyte growth factor (HGF) or vehicle for 2, 8, or 24 hours. HGF stimulates the cMET protein, a tyrosine kinase transmembrane protein. The aim of this study is to determine the role of the HGF/cMET pathway in immature cells of established pr...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-16659 | biostudies-arrayexpress
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