Sort   by:  
 Page size 
ProteomicsSystems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism
submission for the paper "Systems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-09 | MSV000084785 | MassIVE
TranscriptomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [RNA-seq]
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-63497 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer cells NF639 cells original population vs EGCG-resistant population
Overexpression of the epidermal growth factor receptor family member Her-2/neu in breast cancer leads to autophosphorylation of the receptor, and induction of multiple downstream signaling pathways including Akt kinase to NF-B cascade that is associated with poor prognosis. Previously, we demonst...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4140 | biostudies-arrayexpress
TranscriptomicsInhibition of Met results in concomitant inhibition of Akt and STAT3 signaling pathways, while abrogation of negative feedback permits Erk reactivation
Amplification and activation of the Met receptor tyrosine kinase occurs up to 23% of gastric cancers, suggesting that Met is a therapeutic target in these cancers. However, the steady-state signaling events that occur during chronic Met activation, and mechanisms for resistance to Met small-molecul...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-54532 | biostudies-arrayexpress
TranscriptomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-64195 | biostudies-arrayexpress
TranscriptomicsExpression profiling of BRAFV600E melanoma cell lines upon RAF inhibition
Microarray expression analysis to identify global changes in transcription in response to RAF inhibition. Genes under RAF control were identified in a panel of BRAFV600E tumor cells, following the short-term inhibition of RAF using a pan-RAF kinase inhibitor, PLX4032 (Plexxikon). For comparison with...
ORGANISM(S): Homo sapiens 
2010-07-18 | E-GEOD-20051 | biostudies-arrayexpress
UnknownThe RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.
Not available
S-EPMC2930420 | biostudies-literature
TranscriptomicsTranscriptional signature of wounded keratinocytes reveals selective roles for ERK1/2, P38 and PI3K signalling pathways
Covering denuded dermal surface after injury requires migration, proliferation and differentiation of skin keratinocytes. To clarify the major traits controlling these intermingled biological events, we surveyed the genomic modifications occurring during the course of a scratch closure of cultured h...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-6820 | biostudies-arrayexpress
TranscriptomicsActivation of different signaling pathways in the regulation of biological properties of human pancreatic cancer cells by the mucin MUC4 and the oncogenic receptor ErbB2 genes
The mucin MUC4 and its membrane partner the ErbB2 oncogenic receptor are potential actors and partners in pancreatic tumourigenesis. However, the way they function is still largely unknown. We thus undertook in this work to identify the cellular mechanisms and the intracellular signalling pathways u...
ORGANISM(S): Homo sapiens 
2012-03-20 | E-GEOD-31322 | biostudies-arrayexpress
TranscriptomicsExpression data for Lck-Cre, Med23flox/flox and Med23flox/flox;Lck-Cre thymocytes +/- 3hr exposure to plate bound anti-CD3 antibody
MED23, a subunit of the Mediator coactivator complex, is important for the expression of a subset of MAPK/ERK pathway-dependent target genes; however, the genes in this subset varies between cell types. MAPK/ERK pathway-dependent processes are essential for T-cell development and function, but whet...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-57061 | biostudies-arrayexpress
Sort   by:  
 Page size