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TranscriptomicsTranscriptomic characterization of a virulence-deficient phosphatidylcholine-negative Agrobacterium tumefaciens mutant
To learn more about the global effects of phosphatidylcholine (PC)-deficiency in A. tumefaciens, we performed transcriptomic studies comparing the wild type and a PC-deficient DpmtA Dpcs mutant. We expanded the number of affected virulence genes and showed that the loss of PC was correlated with alt...
ORGANISM(S): Agrobacterium tumefaciens str. C58 
2010-04-07 | E-GEOD-21223 | biostudies-arrayexpress
TranscriptomicsStress-related gene expression in HK-2 cells exposed to pH 7.4, 7.0 or 6.7
Chronic metabolic acidosis occurs commonly in patients with diseased kidneys and is linked with progression to renal failure. As renal function declines there is loss of nephron mass and adaptive proximal tubular hypertrophy and hypermetabolism. We have previously demonstrated in an in vitro model o...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-23995 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of lentivirally-transduced rhesus macaque CD34+ cells long-term following transplant
The occurrence of clonal perturbations and leukemia in patients transplanted with retrovirally-transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions perturb adjacent proto-oncogene expression. Although enh...
ORGANISM(S): Macaca mulatta 
2013-11-05 | E-GEOD-46032 | biostudies-arrayexpress
GenomicThe Glaucoma Genes and Environment (GLAUGEN) Study

Background Information: Primary open-angle glaucoma (POAG) is an age-related, intraocular pressure (IOP)-dependent progressive optic neuropathy that ultimately leads to irreversible blindness. Vision loss from POAG is a condition of public health significance. Current evidence suggests tha...

phs000308 | dbGaP
TranscriptomicsArterial vs venous expression of genes: differences in inflammatory genes
Arteries and veins modulate cardiovascular homeostasis and contribute to the pathogenesis of hypertension. Functional differences between normal arteries and veins are based upon differences in gene expression. To better characterize these expression patterns, and to identify candidate genes that ...
ORGANISM(S): Rattus norvegicus 
2009-07-13 | E-GEOD-12255 | biostudies-arrayexpress
TranscriptomicsPF4-Cre mediated deletion of SRF in murine megakaryocytes.
Srf is a MADS-box transcription factor that is critical for muscle differentiation. Its function in hematopoiesis has not yet been revealed. Mkl1, a cofactor of Srf, is part of the t(1;22) translocation in acute megakaryoblastic leukemia, and plays a critical role in megakaryopoiesis. In order to te...
ORGANISM(S): Mus musculus 
2010-07-13 | E-GEOD-21859 | biostudies-arrayexpress
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array)
LIN28 is a conserved RNA binding protein implicated in pluripotency, reprogramming and oncogenesis. Previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) targets. Through cross-linking...
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39855 | biostudies-arrayexpress
TranscriptomicsmRNA Expression Comparison Between Igfbp7-null and wild type mice at Lactation Day 3
Insulin like growth factor binding protein 7, Igfbp7, is a secreted protein that in addition to modulating insulin and insulin-like growth factor signaling, it acts as a tumor suppressor gene in breast and other cancers. To elucidate the role of Igfbp7 in regulating the proliferation and differentia...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-45118 | biostudies-arrayexpress
TranscriptomicsInfluence of oxygen limitation, absence of the cytochrome bc1 complex and low pH on global gene expression in Gluconobacter oxydans 621H using DNA microarray technology
The genome-wide transcriptional responses of the strictly aerobic -proteobacterium Gluconobacter oxydans 621H to oxygen limitation, to the absence of the cytochrome bc1 complex, and to low pH were studied using DNA microarray analyses. Oxygen limitation caused expression changes of 486 genes, repres...
ORGANISM(S): Gluconobacter oxydans 621H 
2012-03-23 | E-GEOD-34294 | biostudies-arrayexpress
TranscriptomicsThe shuttling SR-like proteins Gbp2 and Hrb1 mediate the nuclear export of spliced mRNAs
Three shuttling SR-like proteins exist in Saccharomyces cerevisiae, Npl3, Gbp2 and Hrb1, that are involved in the nuclear export of mRNAs. In a screen for genes that regulate the export of Gbp2, we identified novel mutants of the splicing factors PRP8 and PRP17 that lead to severe mislocalization de...
ORGANISM(S): Saccharomyces cerevisiae 
2013-08-30 | E-GEOD-20738 | biostudies-arrayexpress
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