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ProteomicsSilencing of double stranded RNA sensing is required for early embryonic development
The type I interferon (IFN) response is inactive during early mammalian development and becomes functional only after gastrulation. As a result, the totipotent and pluripotent embryonic stages remain susceptible to pathogens, including viruses. Here, we demonstrate that pluripotent mouse embryonic s...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-26 | PXD059977 | Pride
Chromatin-associated proteomics  mda5  pluripotency stem cells 
ProteomicsControl of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune responses. Here, we show that inactivation of the double stranded RNA (dsRNA)-binding protein DGCR8 unleas...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD074388 | Pride
Interferon response Transposable elements 22qds Human Dsrna Dgcr8 Stem cells Mouse Pa-1 
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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