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ProteomicsCellular dsRNA interactome captured by K1 antibody reveals the regulatory map of exogenous RNA sensing
We developed an anti-dsRNA antibody co-immunoprecipitation coupled with quantitative mass spectrometry to comprehensively identify RBPs bound to cellular dsRNAs. To minimize false positives, we conducted a quantitative mass spectrometry analysis under two additional conditions: first, by treating th...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD053100 | Pride
Dsrna Dsrbp Interferon response Viral infection Mass spectrometry Rna sensing Crispr-cas9 screening Lc-ms/ms 
ProteomicsIdentification of cell membrane proteins involved in dsRNA internalization
Cellular uptake of dsRNA from the environment is a widespread phenomenon among insects. In Drosophila and in honeybees, the injection and the ingestion respectively of dsRNA against a viral sequence is sufficient to hinder virus replication. We wanted to identify cell surface proteins that bind to e...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-11 | PXD034508 | Pride
Rna binding Drosophila 
ProteomicsIdentification of whole-cell dsRNA-binding proteins by phase separation
Interactions between double-stranded RNA (dsRNA) and proteins play an important role in cellular homeostasis by regulating the editing, stability, and splicing of intracellular RNA. The identification of dsRNA-binding proteins (dsRBPs) is key; however, it has long been challenging to purify dsRBPs f...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-10-17 | PXD048971 | Pride
Dsrna-binding domain Dsrna-binding protein capture Armadillo/beta-catenin-like repeats Dsrna-binding proteome Dsrna-binding proteins 
TranscriptomicsUbiquitous expression of long dsRNA in mice causes mainly RNAi effects in the oocyte
Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, such as the sequence-specific RNA interference (RNAi) pathway, the sequence-independent interferon response, and RNA editing by adenosine deaminases. To study routing of long dsRNA into different pathways in different tissu...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-26577 | biostudies-arrayexpress
ProteomicsStructural insights into dsRNA processing by Drosophila Dicer-2/Loqs-PD
Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a conserved RNA silencing mechanism in many eukaryotes. In Drosophila, an RNase III enzyme Dicer-2 (Dcr-2), aided by its cofactor Loquacious-PD (Loqs-PD), plays major role in generating 21 base-pair (bp) siRNA duplex...
ORGANISM(S): Drosophila Melanogaster 
2022-04-21 | PXD033365 |
TranscriptomicsEffects of long dsRNA expression in HeLa and HEK293 cells
Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, including sequence-specific RNA interference, sequence-independent interferon response and editing by adenosine deaminases. To assess the potential of expressed dsRNA to induce interferon stimulated genes in somatic cells, ...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-27316 | biostudies-arrayexpress
Genomicsunclassified dsRNA viruses
unclassified dsRNA viruses
PRJNA16954 | ENA
ProteomicsProteomic analysis of the immune response to dsRNA in B.dorsalis
Proteomic analysis of a mixed sample from 8, 12 and 24 h (early set) post first exposure to dsRNA and a sample from 5 days (late set) post first exposure to dsRNA to identify differentially expressed proteins which were responsible to the immune response to dsRNA in B.dorsalis.
ORGANISM(S): Bactrocera dorsalis 
2018-10-27 | PXD004272 | Pride
Dsrna Immune B.dorsalis Rnai Itraq 
ProteomicsDetermination of dsRNA interactome upon Sindbis virus infection in human cells identifies SFPQ as a critical proviral factor
Viruses are obligate intracellular parasites, which depend on the host cellular machineries to replicate their genome and complete their infectious cycle. Long double stranded (ds)RNA is a common viral by-product originating during RNA virus replication, which is universally sensed as a danger signa...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024554 | Pride
Dsrna Sindbis virus Dsrnaome Sfpq Rbp 
TranscriptomicsTissue Type-Specific Expression of the dsRNA-Binding Protein 76 and Genome-wide Elucidation of its Target mRNAs
RNA-binding proteins accompany all steps in the life of mRNAs and provide dynamic gene regulation functions for rapid adjustment to changing extra- or intracellular conditions. The association of RNA-binding proteins with their targets is regulated through changing sub-cellular distribution, post-tr...
ORGANISM(S): Homo sapiens 
2010-05-04 | E-GEOD-20001 | biostudies-arrayexpress
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