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TranscriptomicsTranscriptomic expression analysis on hippocampus samples
Hippocampus transcriptome analysis of Ms5Yah carrying a 7.7Mb deletion on chromosome 16 and wild-type littermates. We analyzed hippocampi from 8 wild-type and 9 Ms5Yah male mice using the Affymetrix Mouse Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool.
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-58639 | biostudies-arrayexpress
TranscriptomicsAffymetrix expression arrays from heart extracted RNA in Ts65Dn and Ms5Yah and Ts65DnMs5Yah mouse models
Affymetrix Mouse Gene 1.0 ST hydridization using wt extracts from adult mice hearts as controls and Ts65Dn, Ms5Yah and Ts65Dn/Ms5Yah samples.

N = 5 mices per group of genotype.

Goal : assess the gene dosage effect on partial trisomic/monosomic mice modelling human Down syndrome.
ORGANISM(S): Mus musculus 
2011-10-05 | E-MEXP-3355 | biostudies-arrayexpress
TranscriptomicsGene expression signature of cerebellum hypoplasia in a mouse model of Down syndrome (Part I).
We designed a large scale gene expression study in Ts1Cje mice between P0 and P10 in order to measure the effects of trisomy 21 on a large number of samples (56 in total) in a tissue that is affected in Down syndrome (the cerebellum) and to quantify the defect during development in order to correlat...
ORGANISM(S): Mus musculus 
2009-03-31 | E-GEOD-11448 | biostudies-arrayexpress
TranscriptomicsGene expression signature of cerebellum hypoplasia in a mouse model of Down syndrome (Part II).
We designed a large scale gene expression study in cerebellar external granular layer in Ts1Cje mice at P0 in order to measure the effects of trisomy 21 on in a enriched cell population (dissected layer) that is affected in Down syndrome in order to correlate gene expression changes to the phenotype...
ORGANISM(S): Mus musculus 
2008-03-31 | E-GEOD-11472 | biostudies-arrayexpress
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
GenomicsDomains of genomewide gene expression dysregulation in Down syndrome [Dnase HS mapping]
Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we sh...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-55425 | biostudies-arrayexpress
GenomicsDomains of genomewide gene expression dysregulation in Down syndrome [RRBS]
Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we sh...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-55505 | biostudies-arrayexpress
TranscriptomicsDomains of genomewide gene expression dysregulation in Down syndrome [array]
Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we sh...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-55289 | biostudies-arrayexpress
TranscriptomicsDomains of genomewide gene expression dysregulation in Down syndrome [RNA-seq]
Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we sh...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-55504 | biostudies-arrayexpress
ProteomicsM.musculus - Plasma, SC (Imbertetal,scidata2021)
abundance based on Spectral counting, Interaction consistency score: 4.5, Coverage: 2
ORGANISM(S): 10090 
2021-00-00 | 8657263 | PAXDB
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