Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Affymetrix expression arrays from heart extracted RNA in Ts65Dn and Ms5Yah and Ts65DnMs5Yah mouse models

ABSTRACT: Affymetrix Mouse Gene 1.0 ST hydridization using wt extracts from adult mice hearts as controls and Ts65Dn, Ms5Yah and Ts65Dn/Ms5Yah samples.

N = 5 mices per group of genotype.

Goal : assess the gene dosage effect on partial trisomic/monosomic mice modelling human Down syndrome.

ORGANISM(S): Mus musculus

SUBMITTER: HERAULT Yann

PROVIDER: E-MEXP-3355 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

Raveau Matthieu M Lignon Jacques M JM Nalesso Valérie V Duchon Arnaud A Groner Yoram Y Sharp Andrew J AJ Dembele Doulaye D Brault Véronique V Hérault Yann Y

PLoS genetics 20120531 5

Down syndrome (DS) leads to complex phenotypes and is the main genetic cause of birth defects and heart diseases. The Ts65Dn DS mouse model is trisomic for the distal part of mouse chromosome 16 and displays similar features with post-natal lethality and cardiovascular defects. In order to better understand these defects, we defined electrocardiogram (ECG) with a precordial set-up, and we found conduction defects and modifications in wave shape, amplitudes, and durations in Ts65Dn mice. By using ...[more]

PMID: 22693452

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Dataset Information

Affymetrix expression arrays from heart extracted RNA in Ts65Dn and Ms5Yah and Ts65DnMs5Yah mouse models

Publications

The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

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