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ProteomicsLC-MS3 analysis of Herc1-knockout mouse MLL/AF9 acute myeloid leukemia cells
Our CRISPR-based pharmacogenomic screening identified the E3 ubiquitin ligase Herc1 as a key modulator of sensitivity to cytarabine (Ara-C) chemotherapy in the MLL/AF9 (MA) mouse AML model both in vitro and in vivo. To identify the intracellular proteins whose abundance is modulated by Herc1, we per...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-08 | PXD054402 | Pride
Herc1 Mouse Lc-ms3 Acute myeloid leukemia 
UnknownHERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling.
Not available
S-EPMC9837143 | biostudies-literature
UnknownHERC1 Regulates Breast Cancer Cells Migration and Invasion.
Not available
S-EPMC8061768 | biostudies-literature
UnknownThe Downregulation of Both Giant HERCs, HERC1 and HERC2, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation.
Not available
S-EPMC8778248 | biostudies-literature
UnknownThe ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling.
Not available
S-EPMC6972752 | biostudies-literature
TranscriptomicsGenome-wide CRISPR screening identifies the E3 ubiquitin ligase HERC1 as a modulator of the response to nucleoside analogs in acute myeloid leukemia
We identified the Ubiquitin Ligase HERC1 in the context of cytarabine response in a genome-wide CRISPR screen in murine AML. We hypothesized to detect early transciptomic changes in cytarabine treated murine AML cells genetically targeted by using single guide RNAs targeting HERC1 and Non-targeting ...
ORGANISM(S): Mus musculus 
2024-08-02 | GSE273667 | GEO
UnknownThe E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia.
Not available
S-EPMC11497402 | biostudies-literature
GenomicsGenome-wide CRISPR screening identifies the E3 ubiquitin ligase HERC1 as a modulator of the response to nucleoside analogs in acute myeloid leukemia
Genome-wide CRISPR screening identifies the E3 ubiquitin ligase HERC1 as a modulator of the response to nucleoside analogs in acute myeloid leukemia
PRJNA1142585 | ENA
UnknownA nonsense variant in HERC1 is associated with intellectual disability, megalencephaly, thick corpus callosum and cerebellar atrophy.
Not available
S-EPMC4755376 | biostudies-literature
UnknownThe Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner.
Not available
S-EPMC7832311 | biostudies-literature
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