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MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
MetabolomicsMetabolomics profiling (GC-MS and LC-MS) for time-course differentiation of pre-B cells-like (B3 cell line) under the controlled induction of the transcription factor Ikaros (STATegra Project)
The main goal of the project is to develop a new generation of bioinformatics resources for the integrative analysis of multiple types of 'omics data. These resources include both novel statistical methodologies as well as user-friendly software implementations. STATegra methods address many aspects...
2016-12-15 | MTBLS283 | MetaboLights
ProteomicsHuman pancreatic endocrine cells, LC-MS3
FACS isolated human alpha and beta cells were analyzed by TMT 11-plex labeling, Off-line basic pH reversed phase fractionation and LC-MS3 on an Orbitrap Fusion mass spectrometer.
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD011933 | Pride
Human Endocrine cells Tmt 11-plex Lc-ms3 
ProteomicsHuman Hippocampus from Non-Hispanic Whites and African Americans with and without Alzheimer's disease LC-MS3
This study examined global proteomic changes in postmortem hippocampus tissue from Non-Hispanic Whites and African American individuals who were cognitively normal or had Alzheimer's disease using LC-MS3 on an Orbitrap Fusion Lumos. Proteins were quantified in the LC-MS3 experiments using Tandem Mas...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD012114 | Pride
Human Brain Hippocampus Tmt Lc-ms3 
ProteomicsHuman Globus Pallidus (GP) from Non-Hispanic Whites and African Americans with and without Alzheimer's disease LC-MS3
This study examined global proteomic changes in postmortem globus pallidus (GP) tissue from Non-Hispanic Whites and African American individuals who were cognitively normal or had Alzheimer's disease using LC-MS3 on an Orbitrap Fusion Lumos. Proteins were quantified in the LC-MS3 experiments using T...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD014371 | Pride
Human Globus pallidus Brain Tmt Alzheimer's disease Lc-ms3 
ProteomicsHuman Inferior Parietal Lobule (IPL) from Non-Hispanic Whites and African Americans with and without Alzheimer's disease LC-MS3
This study examined global proteomic changes in postmortem inferior parietal lobule (IPL) tissue from Non-Hispanic Whites and African American individuals who were cognitively normal or had Alzheimer's disease using LC-MS3 on an Orbitrap Fusion Lumos. Proteins were quantified in the LC-MS3 experimen...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD014372 | Pride
Human Brain Tmt Inferior parietal lobule Alzheimer's disease Lc-ms3 
ProteomicsLC-MS3 analysis of Herc1-knockout mouse MLL/AF9 acute myeloid leukemia cells
Our CRISPR-based pharmacogenomic screening identified the E3 ubiquitin ligase Herc1 as a key modulator of sensitivity to cytarabine (Ara-C) chemotherapy in the MLL/AF9 (MA) mouse AML model both in vitro and in vivo. To identify the intracellular proteins whose abundance is modulated by Herc1, we per...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-08 | PXD054402 | Pride
Herc1 Mouse Lc-ms3 Acute myeloid leukemia 
UnknownTargeted High Resolution LC/MS3 Adductomics Method for the Characterization of Endogenous DNA Damage.
Not available
S-EPMC6822301 | biostudies-literature
UnknownComparison of LC-MS3 and LC-MRM Methods for Quantifying Amantadine and Its Application in Therapeutic Amantadine Monitoring in Human Plasma.
Not available
S-EPMC9655109 | biostudies-literature
ProteomicsSugarQuant: a streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics
Site-specific regulation of protein N-glycosylation is essential in human cells. However, accurate quantification of glycosylation sites and their individual glycan moieties in a cell-wide manner is still technically challenging. Here, we introduce SugarQuant, an integrated mass spectrometry-based p...
ORGANISM(S): Homo sapiens (Human) 
2020-08-24 | PXD018349 | Pride
Glycosylation 
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