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TranscriptomicsMicroarray characterization of gene expression changes in blood during acute ethanol exposure
As part of the civil aviation safety program to define the adverse effects of ethanol on flying performance, we present results of our DNA microarray analysis of samples from a timecourse study of individuals given ethanol orally, and then evaluated by breathalyzer to monitor blood alcohol content (...
ORGANISM(S): Homo sapiens 
2013-07-25 | E-GEOD-20489 | biostudies-arrayexpress
TranscriptomicsExamining smoking-induced differential gene expression changes in buccal mucosa
A tissue like buccal mucosa (from cheek swabs) would be an ideal sample material for rapid, easy collection for testing of biomarkers as an alternative to blood. A limited number of studies, primarily in the smoker/oral cancer literature, address this tissue's efficacy for quantitative PCR or micro...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-16149 | biostudies-arrayexpress
TranscriptomicsEvidence of Dynamically Dysregulated Gene Expression Pathways in Hyper-responsive B Cells from African American Lupus Patients
In this report we applied standard and original methods of analysis of gene expression microarray data to delineate differences in the molecular pathways impacted by stimulation of Epstein-Barr virus (EBV) transformed B cells derived from patients with systemic lupus erythematosus (SLE) and normal u...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37573 | biostudies-arrayexpress
TranscriptomicsAffymetrix profile of human liver progenitor cells
Human liver progenitor cells (LPCs) show therapeutic potential, however, their in vitro culture results in inadequate function and phenotypic instability reflecting incomplete understanding of in vivo processes. Foetal LPCs capable of differentiation to a hepatocyte phenotype were isolated and mRNA ...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-57812 | biostudies-arrayexpress
TranscriptomicsProfile of human liver progenitor cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-57878 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of hypertensive and hypotensive mice
Hypertension is a condition with major cardiovascular and renal complications, affecting nearly a billion patients worldwide. Few validated gene targets are available for pharmacological intervention, so there is a need to identify new biological pathways regulating blood pressure and containing nov...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-19817 | biostudies-arrayexpress
TranscriptomicsPdx1 maintains ?-cell identity and function by repressing an ?-cell program
To get a more complete picture of the transcriptional changes associated with Pdx1 loss in ?-cells, we conducted an mRNA microarray comparing normal islet ?-cells and a-cells to the reprogrammed cells from PKO mice. Islet beta cells are from mice which has a single copy of Pdx1 flox (Pdx1L/+) allele...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-52258 | biostudies-arrayexpress
TranscriptomicsCopper-regulated genes of Bradyrhizobium japonicum
Copper-limiting growth conditions were thought to cause an induction of genes possibly involved in copper uptake and sorting. This rationale in mind, we performed microarray analyses on B. japonicum cells grown in three variations of the BVM minimal medium. Variant 1 contained 2 M-NM-
ORGANISM(S): Bradyrhizobium japonicum 
2012-10-01 | E-GEOD-40437 | biostudies-arrayexpress
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