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TranscriptomicsExposure to Propylthiouracil in Pregnant Mice Potentiates the Transcriptional Response to Thyroid Hormone in the Fetal Cerebral Cortex
Although the effects of thyroid hormones (TH) on the brain development have been extensively studied perinatally, effects of TH of maternal origin on the fetal brain development have been largely unexplored. We applied a high throughput study on the mouse models with aberrant TH levels on gestation ...
ORGANISM(S): Mus musculus 
2014-02-04 | E-GEOD-43927 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats treated with transient focal ischemia
Large clinical studies have shown that AT1 receptor blockers (ARBs) reduce the incidence of stroke in patients at risk. However, there is controversy about the underlying pathomechanisms. To get a closer insight into the effects of ARBs in stroke on molecular level, gene expression pattern was compa...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-4206 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of right ventricule from arrhythmogenic heterozygous plakoglobin deficient mice undergone endurance training to identify transcriptional responses to training.
Endurance training accelerated development of right ventricular dysfunction and arrhythmias in plakoglobin+/- mice. Histology and electron microscopy did not identify right ventricular abnormalities. To identify differences in the transcriptional response to training gene expression profiling was pe...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-4120 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human inflammatory cardiomyopathy vs controls (DCMi) suggests novel therapeutic targets.
Since targeting of specific pathogenic pathways may be more efficient than current unspecific heart failure treatment, we obtained genomewide expression profiles of a DCM subtype characterized by cardiac inflammation (DCMi) in association with parvovirus B19. This study was entirely based on RNA iso...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4172 | biostudies-arrayexpress
TranscriptomicsVitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line
We describe the changes in gene expression profile of differentiating rat CG4 oligodendrocyte progenitor cell lines treated with either vitamin D2 or D3. The treatment was initiated in cells pre-differentiated for 2 days (time 0) and the changes in gene expression were monitored at 24 h and 72 h pos...
ORGANISM(S): Rattus norvegicus 
2020-07-26 | E-MTAB-8098 | biostudies-arrayexpress
TranscriptomicsCataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pigtail Macaques
Our earlier studies in pig-tailed macaques demonstrated varying SHIV susceptibility during the menstrual cycle, likely caused by cyclic variations in immune responses in the female genital tract. There is concern that high-dose, long-lasting, injectable progestin-based contraception could mimic the...
ORGANISM(S): Macaca nemestrina 
2015-07-08 | E-GEOD-68079 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of pressure overload
Pressure overload (PO) leads first to cardiac hypertrophy and later to heart failure. In mice, PO leads to sex differences in cardiac morphology and function. However, early sex differences in gene regulation that precede sex differences in function have not yet been identified. To identify such c...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6970 | biostudies-arrayexpress
TranscriptomicsFemale sex and oestrogen receptor β attenuate cardiac remodelling and apoptosis in pressure overload
Aims: We investigate sex differences and the role of oestrogen receptor beta (ERbeta) in a mouse model of pressure overload-induced myocardial hypertrophy. Methods and results: We performed transverse aortic constriction (TAC) or sham surgery in male and female wild-type (WT) and ER knockout (ERbet...
ORGANISM(S): Mus musculus 
2010-01-19 | E-GEOD-18224 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human synovial samples from patients with osteoarthritis, rheumatoid arthritis vs controls treated with various drug regimes to characterise RA at the molecular level and to uncover key pathomechanisms
Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced inter-patient heterogeneity. To characterize RA at the molecular level and to uncover key pathomechanisms, we performed whole-genome gene expression analyses. Synovial tissues from rheumatoid arthri...
ORGANISM(S): Homo sapiens 
2004-11-04 | E-GEOD-1919 | biostudies-arrayexpress
TranscriptomicsCorticosteroid treatment of glial cell types
Primary mixed glial cultures were prepared from dissociated cerebral cortices of Sprague-Dawley rats at postnatal day 1 to 3 and glial populations were isolated by sequential rotary shaking procedures using well-established protocols. Cultured cells were exposed to 1 micromol dexamethasone for 24hou...
ORGANISM(S): Rattus norvegicus 
2014-03-08 | E-MTAB-1695 | biostudies-arrayexpress
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