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TranscriptomicsHypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signali...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-35894 | biostudies-arrayexpress
GenomicsesBAF is an essential component of the core pluripotency transcriptional network
Distinctive SWI/SNF-like ATP-dependent chromatin remodeling esBAF complexes are indispensable for the maintenance and pluripotency of mouse embryonic stem (ES) cells. To understand the mechanism underlying the roles of these complexes in ES cells, we performed high-resolution genome-wide mapping of ...
ORGANISM(S): Mus musculus 
2009-01-20 | E-GEOD-14344 | biostudies-arrayexpress
TranscriptomicsPostreplicative recruitment of Cohesin to double-strand breaks
This series is a supplementary data set for the manuscript titled "Postreplicative recruitment of Cohesin to double-strand breaks is required for DNA repair" All data shown in the paper plus duplicate experiments were registered (15 ChIP-chip data). Experimental design: 1. Type of experiment: ChIP...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-27 | E-GEOD-1905 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in neural differentiated mouse embryonic stem cells (mESCs) under exposure to sodium valproate and sodium arsenite
Studying chemical disturbances during neural differentiation of mES cells has been established as an alternative in vitro testing approach for the identification of developmental toxicants. miRNAs represent a class of small regulatory RNA molecules, which bind to target mRNAs thereby repressing thei...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-50216 | biostudies-arrayexpress
TranscriptomicsChromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways
The SMC protein complexes safeguard genomic integrity through their functions in chromosome segregation and repair. The chromosomal localization of the budding yeast Smc5/6 complex here determined reveals that the complex works specifically on the duplicated genome in differently regulated pathways....
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4808 | biostudies-arrayexpress
TranscriptomicsNeural differentiated mouse embryonic stem cells (mESCs) under exposure to sodium valproate and sodium arsenite
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-50217 | biostudies-arrayexpress
TranscriptomicsesBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signaling and by regulating Polycomb function
Signaling by the cytokine LIF and its downstream transcription factor, STAT3, prevents differentiation of pluripotent embryonic stem cells (ESCs) by opposing MAP kinase signaling. This contrasts with most cell types where STAT3 signaling induces differentiation. We find that STAT3 binding across t...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-27708 | biostudies-arrayexpress
TranscriptomicsPost-replicative formation of cohesion is required for repair and induced by a single DNA break
Sister chromatid cohesion, established during replication by the protein complex Cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally cohesion formation is strictly limited to the S-phase of the cell cycle, but DSBs can trigger cohesion also after DNA ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-8270 | biostudies-arrayexpress
TranscriptomicsDeciphering the porcine intestinal microRNA transcriptome
Background While more than 700 microRNAs (miRNAs) are known in human, a comparably low number has been identified in swine. Because of the close phylogenetic distance to humans, pigs serve as a suitable model for studying e.g. intestinal development or disease. Recent studies indicate that miRNAs a...
ORGANISM(S): Sus scrofa 
2010-05-05 | E-GEOD-21628 | biostudies-arrayexpress
TranscriptomicsMyomgraft_Model_TASIP_2010_09
Human uterine fibroids are benign tumors derived from the smooth muscle layers of the uterus. Fibroid disease impacts up to 50% of premenopausal women in their daily life, and accounts for up to 50% of hysterectomies in the United States. Despite the health burden they impose, the development of the...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-MTAB-1882 | biostudies-arrayexpress
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