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Fidaxomicin is considered the current gold standard antibiotic for treating Clostridioides difficile infections and kills bacterial cells by inhibition of the RNA polymerase through binding to its switch region. Although binding sites do not overlap, also Myxopyronin B inhibits the RNA polymerase by...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2021-12-21 | PXD027366 | Pride
Amidochelocardin is an atypical tetracycline which was previously shown to target the bacterial cell membrane although its detailed mode-of-action is still unknown. To gain insight into Clostridioides difficile’s response to membrane targeting antibiotics and to further study the mode-of-action of A...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-08-04 | PXD029250 | Pride

Understanding biogeochemical conversions of dissolved organic matter (DOM) in aquifers is paramount for the effective management of groundwater supplies. On its passage through the critical zone, DOM is subject to biogeochemical conversions and therefore carries cross-habitat information useful f...

2024-10-17 | MTBLS11375 | MetaboLights
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