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TranscriptomicsGlobal characterization of the oocyte-to-embryo transition in C. elegans uncovers a novel mRNA turnover mechanism
The oocyte-to-embryo transition (OET) is thought to be mainly driven by post-transcriptional gene regulation. However, expression of both RNAs and proteins during the OET has not been comprehensively assayed. Furthermore, specific molecular mechanisms that regulate gene expression during OET are lar...
ORGANISM(S): Caenorhabditis elegans 
2014-07-02 | E-GEOD-58141 | biostudies-arrayexpress
TranscriptomicsUnambiguous Identification of miRNA:target site Interactions by Different Types of Ligation Reactions
To exert regulatory function, miRNAs guide Argonaute (AGO) proteins to partially complementary sites on target RNAs. Crosslinking and immunoprecipitation (“re state-of-the-art to map AGO binding sites, but assigning the targeting miRNA to these sites relies on bioinformatics predictions and is there...
ORGANISM(S): Caenorhabditis elegans 
2014-05-23 | E-GEOD-56180 | biostudies-arrayexpress
TranscriptomicsCircular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed
Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using t...
ORGANISM(S): Homo sapiens 
2015-04-24 | E-GEOD-65926 | biostudies-arrayexpress
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