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TranscriptomicsEffects of miRNA sponge/decoy-mediated reduction of miR-15 family activity on the transcriptome of B cell precursors
A common experimental setup to investigate the function of a microRNA is a â??gain-of-functionâ?? approach, in which the microRNA of interest is overexpressed to analyze its impact on a given process. However, a major drawback of this technique is that microRNAs, when expressed significantly above e...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-72767 | biostudies-arrayexpress
TranscriptomicsEffects of miR-125b expression on the transcriptome of B cell precursors
Here, we have screened a miRNA expression library in a pre-B cell expression system to identify miRNAs with a potential oncogenic activity in early lymphocytes. We show that miR-125b is sufficient to transform B cell precursors in vitro as defined by growth factor independence, and demonstrate that ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-59994 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
TranscriptomicsGene expression data of interleukin-7-dependent and BCR-ABL1-transformed pre-B cells
This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress during pre-B cell differentiation. Differentiation of pre-B cells including immunoglobulin light chain gene recombination were performed by withdrawal of interleuki...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21664 | biostudies-arrayexpress
TranscriptomicsCircular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed
Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using t...
ORGANISM(S): Homo sapiens 
2015-04-24 | E-GEOD-65926 | biostudies-arrayexpress
UnknownExpanding the Spectrum of BAF-Related Disorders: De Novo Variants in SMARCC2 Cause a Syndrome with Intellectual Disability and Developmental Delay.
Not available
S-EPMC6323608 | biostudies-literature
UnknownSafety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation.
Not available
S-EPMC11249957 | biostudies-literature
UnknownApolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
Not available
S-EPMC9422774 | biostudies-literature
UnknownLipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.
Not available
S-EPMC8822604 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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