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TranscriptomicsTranscription profiling of human tetracycline-regulated cell line expressing an NF-kB inhibitor to systematically identify NF-kB dependent genes
TNF time course series of HelA tet off cells cultured in presence or absence of Dox; TNF is a pro-inflammatory cytokine that controls expression of inflammatory genetic networks. Although the Nuclear Factor-kB (NF-kB) pathway is crucial for mediating cellular TNF responses, the complete spectrum of...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2624 | biostudies-arrayexpress
TranscriptomicsHuman keratinocytes have a response to injury that upregulates CCL20 and other genes linking innate and adaptive immunity
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive ...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-30355 | biostudies-arrayexpress
TranscriptomicsSucrose modulation of the Arabidopsis thaliana guard-cell transcriptome
Microarrays were used to evaluate the effect of sucrose on gene expression in guard cells. Strips of Arabidopsis leaves were incubated with sucrose or mannitol or no sugars, then the leaves were freeze dried and guard cells were dissected from the leaf strips and analyzed. RNA was extracted from gu...
ORGANISM(S): Arabidopsis thaliana 
2012-11-26 | E-GEOD-37408 | biostudies-arrayexpress
TranscriptomicsToxoplasma gondii arginine methyltransferase 1 (PRMT1) regulates parasite counting during tachyzoite cell division
PRMT1 is thought to be responsible for the majority of PRMT activity in Toxoplasma gondii, but its exact function is unknown. We generated T. gondii mutants lacking PRMT1 (∆prmt1) by deletion of the PRMT1 gene. ∆prmt1 parasites exhibit morphological defects during cell division and grow slowly, and ...
ORGANISM(S): Toxoplasma gondii 
2015-09-18 | E-GEOD-73177 | biostudies-arrayexpress
TranscriptomicsIL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesis
In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines together. We reveal a dichotomous effect of IL-17 and TNF, which not only elicit essential mitogenic cytokines but also suppress melanogenesis by down-regulating genes of...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-40413 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of a chronic in vitro model of Parkinsonism
The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT) has been linked to Parkinson disease (PD) etiology and is often used to model this neurodegenerative disease (ND). Many of the mechanisms of action of rotenone are posited mechanisms o...
ORGANISM(S): Homo sapiens 
2012-08-08 | E-GEOD-35642 | biostudies-arrayexpress
Transcriptomics3 Week IV Study of RGMC Ab in Female Sprague Dawley Rats
High levels of hepcidin, the main regulator of systemic iron metabolism leads to various diseases. Targeting hepcidin and lowering its concentration is a possible form of intervention in order to treat these diseases. High turnover rate of hepcidin is a major drawback of therapies directly targeting...
ORGANISM(S): Rattus norvegicus 
2014-11-14 | E-GEOD-63200 | biostudies-arrayexpress
UnknownEfficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial.
Not available
S-EPMC8523116 | biostudies-literature
UnknownBaricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial.
Not available
S-EPMC9126560 | biostudies-literature
UnknownImmunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials.
Not available
S-EPMC10867612 | biostudies-literature
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