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TranscriptomicsRNAseq of 4 day old etiolated Arabidopsis thaliana Ler and gin2-1 seedlings grown in darkness at 18C
Post-germination, emerging seedlings rely on storage reserves to fuel cellular metabolism until photoautotrophic growth is established. Seed reserves can also sustain growth when seedlings are occluded from light, by for instance, soil or debris, which delays the switch to photosynthesis-driven grow...
ORGANISM(S): Arabidopsis thaliana 
2023-05-24 | E-MTAB-7654 | biostudies-arrayexpress
TranscriptomicsAnalyses of Human Brain Metastases of Breast Cancer Reveal the Association between HK2 Up-Regulation and Poor Prognosis
Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis. Brain metastases of breast cancer seem to be increasing in incidence as systemic therapy improves. Metastatic disease in the brain is associated with high mor...
ORGANISM(S): Homo sapiens 
2010-01-21 | E-GEOD-20016 | biostudies-arrayexpress
TranscriptomicsmicroRNA-143 downregulates Hexokinase 2 in colon cancer cells
MicroRNAs (miRNAs) have emerged as important gene regulators and are recognized as key players in tumorigenesis. miR-143 is reported to be down-regulated in several cancers, but knowledge of its targets in colon cancer remains limited. To investigate the role of miR-143 in colon cancer, we have empl...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-33420 | biostudies-arrayexpress
TranscriptomicsHexokinase 2 detects cytokeratin negative circulating tumor cells in lung adenocarcinoma
Circulating tumor cells (CTCs) represent the molecular characteristics of tumor sites and travel in the blood for seeding distant metastases. "EpCAM+/pan-cytokeratin (CK)+/CD45-/DAPI+" has been widely accepted as a CTC definition, especially in breast cancer, prostate cancer and colorectal cancer. H...
ORGANISM(S): Homo sapiens 
2021-02-28 | E-MTAB-8767 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis to identify genes responsive to non-metabolised glucose analogs: approach to hexokinase-independent glucose sensing
It has been strongly argued that plant cells should have a means of sensing sugars at the cell surface, so that extracellular and intracellular sugars can be sensed separately and their metabolism coordinated (Lalonde et al., Plant Cell, 11, 707-26, 2000). There is good evidence for an intracellular...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5723 | biostudies-arrayexpress
ProteomicsHexokinase 2 is a transcriptional targetHexokinase 2 is a transcriptional target and a positive modulator of AHR signalling and a positive modulator of AHR signalling
The Aryl Hydrocarbon Receptor (AHR) regulates the expression of numerous genes in response to activation by agonists including xenobiotics. Although it is well appreciated that environmental signals and cell intrinsic features may modulate this transcriptional response, how it is mechanistically ach...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD028992 | Pride
Human  iosteosarcoma  hexokinase 2  ahr 
ProteomicsComparative analysis of mouse muscles types
The dataset presents FASP- and LC-MS/MS-based analysis of whole lysates of tree types of mouse muscle tissue: white and red muscle fibers and heart muscle. The measurements were performed using five biological replicates for each tissue type. The dataset cover 7200 proteins. The data were used for ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-07 | MSV000084934 | MassIVE
ProteomicsiTRAQ Analysis of DJ-1 Knockout Rodent Brains
Mutations in the DJ-1 (Park7) gene cause autosomal recessive Parkinson's disease in humans, but the function of the DJ-1 protein is poorly characterized. In an effort to understand more about the biology of DJ-1, we performed iTRAQ analyses on subcellular fractions enriched from DJ-1 knockout rat an...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2017-10-04 | PXD005215 | Pride
Cytosol Itraq Dj-1 Mitochondria Hexokinase Parkinson's Neurodegeneration Subcellular fractionation Aging 
UnknownKRAS4A directly regulates hexokinase 1.
Not available
S-EPMC6923592 | biostudies-literature
ProteomicsArabidopsis thaliana non aqueous fractionation LC-MS/MS analysis of genotypes Ler (Landsberg erecta) and gin2-1 (glucose insensitive (hexokinase 1)) time series analysis under normal, chilling temperature and highlight+heat.
Plant cells are characterized by a high degree of compartmentalization and a diverse proteome and metabolome. Only a very limited number of studies has addressed combined subcellular proteomics and metabolomics which strongly limits biochemical and physiological interpretation of large-scale omics d...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-08-05 | PXD013646 | Pride
Arabidopsis thaliana Time series Subcellular protein marker Subcellular analysis Hexokinase 1 Cold Highlight Non aqueous fractionation Photorespiration Gin2-1 
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