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TranscriptomicsMicroRNA expression in normal and tumor breast tissues
microRNA expression signatures can differentiate normal and breast cancer tissues and can define specific clinico-pathological phenotypes in breast tumors. In order to further evaluate the microRNA expression profile in breast cancer, we analyzed the expression of 667 microRNAs in 29 tumors and 21 a...
ORGANISM(S): Homo sapiens 
2012-03-10 | E-GEOD-35412 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for lung cancer samples
Lung cancer is the leading cause of death from malignant diseases worldwide, with the non-small cell (NSCLC) subtype accounting for the majority of cases. NSCLC is characterized by frequent genomic imbalances and copy number variations (CNVs), but the epigenetic aberrations that are associated with ...
ORGANISM(S): Homo sapiens 
2014-12-10 | E-GEOD-62407 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ervical and skin tissues from HPV 16 E6 transgenic animals
Background; The in vivo properties of HR-HPV E6 and E7 oncoproteins have been previously evaluated through the generation and characterization of HPV transgenic mouse strains. Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignan...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-10702 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for DNA copy number analysis of supernatant DNA
DNA contained in the supernatant of cultured malignant cells as well as from plasma/serum of cancer patients is able to transform recipient immortal murine NIH3T3 cells. We demonstrate for the first time that human circulating DNA is able to drive tumor progression in an immunocompetent colon carcin...
ORGANISM(S): Homo sapiens 
2012-07-08 | E-GEOD-35052 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for breast cancer samples
Chromosomal structural mutations play an important role in determining the transcriptional landscape of human breast cancers. We determined that pro-oncogenic and anti-oncogenic genes are clustered throughout the genome and that these clusters coincide with regions of segmental amplification and de...
ORGANISM(S): Homo sapiens 
2013-06-29 | E-GEOD-48377 | biostudies-arrayexpress
UnknownThe effects of death and post-mortem cold ischemia on human tissue transcriptomes.
Not available
S-EPMC5811508 | biostudies-literature
TranscriptomicsGenome-wide mRNA expression profiles induced by infection with the pandemic and seasonal influenza A viruses in macrophages
Infection with pandemic A/H1N1 influenza virus induces high levels of circulating and lung pro-inflammatory cytokines and chemokines in experimental models and humans. These inflammatory mediators contribute to poor clinical outcomes of this infection. To compare the regulation of inflammatory respo...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-36012 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model
HPV16 E7 oncoprotein expression in K14E7 transgenic mice induces cervical cancer after 6 months of treatment with the co-carcinogen 17M-NM-2-estradiol. In untreated mice, E7 also induces skin tumors late in life, albeit at low penetrance. These findings indicate that E7 alters cellular functions in ...
ORGANISM(S): Mus musculus 
2012-06-09 | E-GEOD-36219 | biostudies-arrayexpress
TranscriptomicsChanges in global gene expression profiles induced by HPV 16 E6 oncoprotein variants in cervical carcinoma C33-A cells
We analyzed the effects of the expression of HPV 16 E6 oncoprotein variants (AA-a, AA-c, E-A176/G350, E-C188/G350, E-G350), and the E- Prototype in global gene expression profiles in an in vitro model. E6 gene was cloned into an expression vector fused to GFP and was transfected in C33-A cells. A...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-73761 | biostudies-arrayexpress
TranscriptomicsGene expression profile associated with the PDZ ligand-motif of HPV16-E6 oncoprotin in the skin of transgenic mice models
The K14E6 transgenic mice developskin hyperplasia,benign tumors and skin cancer. The tumor formation capacity diminishes when E6 lacks its PDZ ligand-motif. This study aims to compare the transciptional profiles of transgenic K14E6 mice with K14E6 Δ146-151 (lacking the PDZ domain) in order to explor...
ORGANISM(S): Mus musculus 
2010-07-27 | E-GEOD-22417 | biostudies-arrayexpress
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